TY - JOUR
T1 - Individualized versus Fixed Positive End-expiratory Pressure for Intraoperative Mechanical Ventilation in Obese Patients
T2 - A Secondary Analysis
AU - PROBESE Investigators of the Protective Ventilation Network and the Clinical Trial Network of the European Society of Anesthesiology
AU - Simon, Philipp
AU - Girrbach, Felix
AU - Petroff, David
AU - Schliewe, Nadja
AU - Hempel, Gunther
AU - Lange, Mirko
AU - Bluth, Thomas
AU - Gama de Abreu, Marcelo
AU - Beda, Alessandro
AU - Schultz, Marcus J
AU - Pelosi, Paolo
AU - Reske, Andreas W
AU - Wrigge, Hermann
AU - Study group members AMC, null
AU - Hollmann, Markus W.
AU - Preckel, Prof. dr. , Benedikt
N1 - Publisher Copyright: © 2021 Lippincott Williams and Wilkins. All rights reserved. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/6
Y1 - 2021/6
N2 - Background: General anesthesia may cause atelectasis and deterioration in oxygenation in obese patients. The authors hypothesized that individualized positive end-expiratory pressure (PEEP) improves intraoperative oxygenation and ventilation distribution compared to fixed PEEP. Methods: This secondary analysis included all obese patients recruited at University Hospital of Leipzig multicenter Protective Intraoperative Ventilation with Higher versus Lower Levels of Positive End-Expiratory Pressure in Obese Patients (PROBESE) trial (n = 42) and likewise all obese patients from a local single-center trial (n = 54). Inclusion criteria for both trials were elective laparoscopic abdominal surgery, body mass index greater than or equal to 35 kg/m 2, and Assess Respiratory Risk in Surgical Patients in Catalonia (ARISCAT) score greater than or equal to 26. Patients were randomized to PEEP of 4 cm H 2O (n = 19) or a recruitment maneuver followed by PEEP of 12 cm H 2O (n = 21) in the PROBESE study. In the single-center study, they were randomized to PEEP of 5 cm H 2O (n = 25) or a recruitment maneuver followed by individualized PEEP (n = 25) determined by electrical impedance tomography. Primary endpoint was Pao 2/inspiratory oxygen fraction before extubation and secondary endpoints included intraoperative tidal volume distribution to dependent lung and driving pressure. Results: Ninety patients were evaluated in three groups after combining the two lower PEEP groups. Median individualized PEEP was 18 (interquartile range, 16 to 22; range, 10 to 26) cm H 2O. Pao 2/inspiratory oxygen fraction before extubation was 515 (individual PEEP), 370 (fixed PEEP of 12 cm H 2O), and 305 (fixed PEEP of 4 to 5 cm H 2O) mmHg (difference to individualized PEEP, 145; 95% CI, 91 to 200; P < 0.001 for fixed PEEP of 12 cm H 2O and 210; 95% CI, 164 to 257; P < 0.001 for fixed PEEP of 4 to 5 cm H 2O). Intraoperative tidal volume in the dependent lung areas was 43.9% (individualized PEEP), 25.9% (fixed PEEP of 12 cm H 2O) and 26.8% (fixed PEEP of 4 to 5 cm H 2O) (difference to individualized PEEP: 18.0%; 95% CI, 8.0 to 20.7; P < 0.001 for fixed PEEP of 12 cm H 2O and 17.1%; 95% CI, 10.0 to 20.6; P < 0.001 for fixed PEEP of 4 to 5 cm H 2O). Mean intraoperative driving pressure was 9.8 cm H 2O (individualized PEEP), 14.4 cm H 2O (fixed PEEP of 12 cm H 2O), and 18.8 cm H 2O (fixed PEEP of 4 to 5 cm H 2O), P < 0.001. Conclusions: This secondary analysis of obese patients undergoing laparoscopic surgery found better oxygenation, lower driving pressures, and redistribution of ventilation toward dependent lung areas measured by electrical impedance tomography using individualized PEEP. The impact on patient outcome remains unclear.
AB - Background: General anesthesia may cause atelectasis and deterioration in oxygenation in obese patients. The authors hypothesized that individualized positive end-expiratory pressure (PEEP) improves intraoperative oxygenation and ventilation distribution compared to fixed PEEP. Methods: This secondary analysis included all obese patients recruited at University Hospital of Leipzig multicenter Protective Intraoperative Ventilation with Higher versus Lower Levels of Positive End-Expiratory Pressure in Obese Patients (PROBESE) trial (n = 42) and likewise all obese patients from a local single-center trial (n = 54). Inclusion criteria for both trials were elective laparoscopic abdominal surgery, body mass index greater than or equal to 35 kg/m 2, and Assess Respiratory Risk in Surgical Patients in Catalonia (ARISCAT) score greater than or equal to 26. Patients were randomized to PEEP of 4 cm H 2O (n = 19) or a recruitment maneuver followed by PEEP of 12 cm H 2O (n = 21) in the PROBESE study. In the single-center study, they were randomized to PEEP of 5 cm H 2O (n = 25) or a recruitment maneuver followed by individualized PEEP (n = 25) determined by electrical impedance tomography. Primary endpoint was Pao 2/inspiratory oxygen fraction before extubation and secondary endpoints included intraoperative tidal volume distribution to dependent lung and driving pressure. Results: Ninety patients were evaluated in three groups after combining the two lower PEEP groups. Median individualized PEEP was 18 (interquartile range, 16 to 22; range, 10 to 26) cm H 2O. Pao 2/inspiratory oxygen fraction before extubation was 515 (individual PEEP), 370 (fixed PEEP of 12 cm H 2O), and 305 (fixed PEEP of 4 to 5 cm H 2O) mmHg (difference to individualized PEEP, 145; 95% CI, 91 to 200; P < 0.001 for fixed PEEP of 12 cm H 2O and 210; 95% CI, 164 to 257; P < 0.001 for fixed PEEP of 4 to 5 cm H 2O). Intraoperative tidal volume in the dependent lung areas was 43.9% (individualized PEEP), 25.9% (fixed PEEP of 12 cm H 2O) and 26.8% (fixed PEEP of 4 to 5 cm H 2O) (difference to individualized PEEP: 18.0%; 95% CI, 8.0 to 20.7; P < 0.001 for fixed PEEP of 12 cm H 2O and 17.1%; 95% CI, 10.0 to 20.6; P < 0.001 for fixed PEEP of 4 to 5 cm H 2O). Mean intraoperative driving pressure was 9.8 cm H 2O (individualized PEEP), 14.4 cm H 2O (fixed PEEP of 12 cm H 2O), and 18.8 cm H 2O (fixed PEEP of 4 to 5 cm H 2O), P < 0.001. Conclusions: This secondary analysis of obese patients undergoing laparoscopic surgery found better oxygenation, lower driving pressures, and redistribution of ventilation toward dependent lung areas measured by electrical impedance tomography using individualized PEEP. The impact on patient outcome remains unclear.
UR - http://www.scopus.com/inward/record.url?scp=85105935372&partnerID=8YFLogxK
U2 - https://doi.org/10.1097/ALN.0000000000003762
DO - https://doi.org/10.1097/ALN.0000000000003762
M3 - Article
C2 - 33843980
SN - 0003-3022
VL - 134
SP - 887
EP - 900
JO - Anesthesiology
JF - Anesthesiology
ER -