Inflammation and depression in young people: a systematic review and proposed inflammatory pathways

Yara J. Toenders, Liliana Laskaris, Christopher G. Davey, Michael Berk, Yuri Milaneschi, Femke Lamers, Brenda W. J. H. Penninx, Lianne Schmaal

Research output: Contribution to journalReview articleAcademicpeer-review

17 Citations (Scopus)


Depression onset peaks during adolescence and young adulthood. Current treatments are only moderately effective, driving the search for novel pathophysiological mechanisms underlying youth depression. Inflammatory dysregulation has been shown in adults with depression, however, less is known about inflammation in youth depression. This systematic review identified 109 studies examining the association between inflammation and youth depression and showed subtle evidence for inflammatory dysregulation in youth depression. Longitudinal studies support the bidirectional association between inflammation and depression in youth. We hypothesise multiple inflammatory pathways contributing to depression. More research is needed on anti-inflammatory treatments, potentially tailored to individual symptom profiles.
Original languageEnglish
Pages (from-to)315-327
Number of pages13
JournalMolecular psychiatry
Issue number1
Early online date2021
Publication statusPublished - Jan 2022

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