Inflammation markers in relation to cognition in a healthy aging population

C. E. Teunissen; M. P.J. Van Boxtel; H. Bosma; E. Bosmans; J. Delanghe; C. De Bruijn; A. Wauters; M. Maes; J. Jolles; H. W.M. Steinbusch; J. De Vente

doi:https://doi.org/10.1016/S0165-5728(02)00398-3

Inflammation markers in relation to cognition in a healthy aging population

C. E. Teunissen, M. P.J. Van Boxtel, H. Bosma, E. Bosmans, J. Delanghe, C. De Bruijn, A. Wauters, M. Maes, J. Jolles, H. W.M. Steinbusch, J. De Vente

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256 Citations (Scopus)

Abstract

The relation between serum inflammatory protein levels and cognitive performance was investigated in a healthy population. Individuals were tested during 6 years of follow-up. Serum concentrations of 10 inflammatory proteins were correlated to cognitive speed (Letter-Digit Coding Test, LDCT), attention and information processing (Stroop) and memory (Word Learning). Haptoglobin levels at baseline correlated negatively with cognitive performance on the Stroop and Word Learning Recall test over the 6 years follow-up period. C-reactive protein (CRP) levels at baseline correlated negatively with performance on the Word Learning tests over the 6 years follow-up period. Thus, relatively high concentrations of haptoglobin and C-reactive protein may be indicative for impaired cognitive performance.

Original language	English
Pages (from-to)	142-150
Number of pages	9
Journal	Journal of Neuroimmunology
Volume	134
Issue number	1-2
DOIs	https://doi.org/10.1016/S0165-5728(02)00398-3
Publication status	Published - Jan 2003

Keywords

Age-related
C-reactive protein
Cognitive performance
Haptoglobin
Interleukins
Longitudinal follow-up

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https://doi.org/10.1016/S0165-5728(02)00398-3

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title = "Inflammation markers in relation to cognition in a healthy aging population",

abstract = "The relation between serum inflammatory protein levels and cognitive performance was investigated in a healthy population. Individuals were tested during 6 years of follow-up. Serum concentrations of 10 inflammatory proteins were correlated to cognitive speed (Letter-Digit Coding Test, LDCT), attention and information processing (Stroop) and memory (Word Learning). Haptoglobin levels at baseline correlated negatively with cognitive performance on the Stroop and Word Learning Recall test over the 6 years follow-up period. C-reactive protein (CRP) levels at baseline correlated negatively with performance on the Word Learning tests over the 6 years follow-up period. Thus, relatively high concentrations of haptoglobin and C-reactive protein may be indicative for impaired cognitive performance.",

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AU - Teunissen, C. E.

AU - Van Boxtel, M. P.J.

AU - Bosma, H.

AU - Bosmans, E.

AU - Delanghe, J.

AU - De Bruijn, C.

AU - Wauters, A.

AU - Maes, M.

AU - Jolles, J.

AU - Steinbusch, H. W.M.

AU - De Vente, J.

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AB - The relation between serum inflammatory protein levels and cognitive performance was investigated in a healthy population. Individuals were tested during 6 years of follow-up. Serum concentrations of 10 inflammatory proteins were correlated to cognitive speed (Letter-Digit Coding Test, LDCT), attention and information processing (Stroop) and memory (Word Learning). Haptoglobin levels at baseline correlated negatively with cognitive performance on the Stroop and Word Learning Recall test over the 6 years follow-up period. C-reactive protein (CRP) levels at baseline correlated negatively with performance on the Word Learning tests over the 6 years follow-up period. Thus, relatively high concentrations of haptoglobin and C-reactive protein may be indicative for impaired cognitive performance.

KW - Age-related

KW - C-reactive protein

KW - Cognitive performance

KW - Haptoglobin

KW - Interleukins

KW - Longitudinal follow-up

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Inflammation markers in relation to cognition in a healthy aging population

Abstract

Keywords

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