Inflammation markers in relation to cognition in a healthy aging population

C. E. Teunissen, M. P.J. Van Boxtel, H. Bosma, E. Bosmans, J. Delanghe, C. De Bruijn, A. Wauters, M. Maes, J. Jolles, H. W.M. Steinbusch, J. De Vente

Research output: Contribution to journalArticleAcademicpeer-review

133 Citations (Scopus)


The relation between serum inflammatory protein levels and cognitive performance was investigated in a healthy population. Individuals were tested during 6 years of follow-up. Serum concentrations of 10 inflammatory proteins were correlated to cognitive speed (Letter-Digit Coding Test, LDCT), attention and information processing (Stroop) and memory (Word Learning). Haptoglobin levels at baseline correlated negatively with cognitive performance on the Stroop and Word Learning Recall test over the 6 years follow-up period. C-reactive protein (CRP) levels at baseline correlated negatively with performance on the Word Learning tests over the 6 years follow-up period. Thus, relatively high concentrations of haptoglobin and C-reactive protein may be indicative for impaired cognitive performance.

Original languageEnglish
Pages (from-to)142-150
Number of pages9
JournalJournal of Neuroimmunology
Issue number1-2
Publication statusPublished - Jan 2003


  • Age-related
  • C-reactive protein
  • Cognitive performance
  • Haptoglobin
  • Interleukins
  • Longitudinal follow-up

Cite this