TY - JOUR
T1 - Inflammatory and Neuronal Biomarkers Associated With Retinal Thinning in Pediatric HIV
AU - Blokhuis, Charlotte
AU - Doeleman, Susanne
AU - Cohen, Sophie
AU - Demirkaya, Nazli
AU - Scherpbier, Henriëtte J.
AU - Kootstra, Neeltje A.
AU - Kuhle, Jens
AU - Teunissen, Charlotte E.
AU - Verbraak, Frank D.
AU - Pajkrt, Dasja
PY - 2017
Y1 - 2017
N2 - PURPOSE. The pathophysiology of neuroretinal thinning in children with human immunodeficiency virus (HIV) is poorly understood. The current study aimed to assess whether neuroretinal thinning in clinically stable perinataly HtV-infected children was associated with biomarkers of immune activation, inflammation, and neuronal damage. METHODS. Inflammation-associated and neuronal damage markers were measured in blood and cerebrospinal fluid (CSF) of HIV-infected children aged 8 to 18 years. Using mixed-effects regression analyses, we assessed associations between these biomarkers and neuroretinal layer thickness, as measured with spectral-domain optical coherence tomography. RESULTS. Thirty-two HtV-infected children (median age 13.6 years, 50% male) were included. Blood plasma levels of interleukin-6, monocyte chemoattractant protein-i, and soluble intercellular adhesion molecule-1 were inversely correlated with foveal inner plexiform layer thickness (coef= -4.40, P <0.001; coef = -9.67, P = 0.047; coef= -10.48, P = 0.042, respectively). Plasma interleukin-6 was inversely correlated with foveal ganglion cell layer thickness (coef = -2.49, P = 0.010). Total Tan levels in CSF were inversely correlated with outer nuclear layer and inner segments thickness (foveal: coef = -19.3, P = 0.029; pericentral: coef 18.09, P = 0.006) and pericentral total retinal thickness (coef= -28.2, P = 0.017). CONCLUSIONS. Neuroretinal thinning was associated with inflammation-associated and neuronal injury biomarkers in a cohort of antiretroviral therapy-treated perinatally HWV-infected children. These findings suggest that ongoing immune activation, inflammation, and neuronal injury occur in parallel with retinal thinning in pediatric HV
AB - PURPOSE. The pathophysiology of neuroretinal thinning in children with human immunodeficiency virus (HIV) is poorly understood. The current study aimed to assess whether neuroretinal thinning in clinically stable perinataly HtV-infected children was associated with biomarkers of immune activation, inflammation, and neuronal damage. METHODS. Inflammation-associated and neuronal damage markers were measured in blood and cerebrospinal fluid (CSF) of HIV-infected children aged 8 to 18 years. Using mixed-effects regression analyses, we assessed associations between these biomarkers and neuroretinal layer thickness, as measured with spectral-domain optical coherence tomography. RESULTS. Thirty-two HtV-infected children (median age 13.6 years, 50% male) were included. Blood plasma levels of interleukin-6, monocyte chemoattractant protein-i, and soluble intercellular adhesion molecule-1 were inversely correlated with foveal inner plexiform layer thickness (coef= -4.40, P <0.001; coef = -9.67, P = 0.047; coef= -10.48, P = 0.042, respectively). Plasma interleukin-6 was inversely correlated with foveal ganglion cell layer thickness (coef = -2.49, P = 0.010). Total Tan levels in CSF were inversely correlated with outer nuclear layer and inner segments thickness (foveal: coef = -19.3, P = 0.029; pericentral: coef 18.09, P = 0.006) and pericentral total retinal thickness (coef= -28.2, P = 0.017). CONCLUSIONS. Neuroretinal thinning was associated with inflammation-associated and neuronal injury biomarkers in a cohort of antiretroviral therapy-treated perinatally HWV-infected children. These findings suggest that ongoing immune activation, inflammation, and neuronal injury occur in parallel with retinal thinning in pediatric HV
U2 - https://doi.org/10.1167/iovs.17-22252
DO - https://doi.org/10.1167/iovs.17-22252
M3 - Article
C2 - 29183044
SN - 0146-0404
VL - 58
SP - 5985
EP - 5992
JO - Investigative Ophthalmology & Visual Science
JF - Investigative Ophthalmology & Visual Science
IS - 13
ER -