Inflammatory myofibroblastic tumour of the central airways: treatment and molecular analysis

Aparna Iyer, Teodora Radonic, Lukas C Heukamp, Erik Thunnissen, Johannes M A Daniels

Research output: Contribution to journalReview articleAcademicpeer-review


Inflammatory myofibroblastic tumours (IMT) are a rare cause of endobronchial masses in adults. Surgery has been the mainstay of treatment of endobronchial IMTs, based on the potential for recurrence. Interventional pulmonology has emerged as a minimally invasive and lung function preserving modality in management of airway obstruction due to tumours. We present a series of three adult patients with IMT treated endobronchially with a short discussion on its potential role. We also discuss how molecular analysis of IMTs for mutations in genes such as ALK and ROS1 might provide insights into clinical behaviour and potential targetable therapy in advanced, unresectable and metastatic cases.

Original languageEnglish
JournalERJ open research
Issue number1
Publication statusPublished - Jan 2021

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