TY - JOUR
T1 - Innate lymphoid cells: from helper to killer
AU - Krabbendam, Lisette
AU - Bernink, Jochem H.
AU - Spits, Hergen
N1 - Funding Information: HS consults for GSK, UniQure and AIMM therapeutics. HS was supported by an advanced grant from the European Research Council (Nr 341038 ) and JB was supported by a Veni grant from ZonMW (Nr 091 501 61 81 01 07 ) and a young investigator grant from the Dutch Lung foundation (Nr 4.2.18.237JO ). Funding Information: HS consults for GSK, UniQure and AIMM therapeutics. HS was supported by an advanced grant from the European Research Council (Nr 341038) and JB was supported by a Veni grant from ZonMW (Nr 091 501 61 81 01 07) and a young investigator grant from the Dutch Lung foundation (Nr 4.2.18.237JO). Publisher Copyright: © 2020 The Authors
PY - 2021/2/1
Y1 - 2021/2/1
N2 - Five subsets of ILCs are extensively described, Lymphoid Tissue inducer (LTi) cells, cytotoxic NK cells and non-cytotoxic helper ILC1s, ILC2s and ILC3s. So far, the main focus has been on the potent cytokine production by helper ILCs and their plastic nature that allows them to switch function and phenotype upon environmental changes. Recent advances in the field indicate the presence of cytotoxic helper ILCs that are distinct from conventional NK cells. In humans, these cytotoxic ILCs can develop from conventional helper ILCs whereas in mice this remains to be elucidated. In this review we discuss the identification, development and function of cytotoxic helper ILCs subsets in humans and mice.
AB - Five subsets of ILCs are extensively described, Lymphoid Tissue inducer (LTi) cells, cytotoxic NK cells and non-cytotoxic helper ILC1s, ILC2s and ILC3s. So far, the main focus has been on the potent cytokine production by helper ILCs and their plastic nature that allows them to switch function and phenotype upon environmental changes. Recent advances in the field indicate the presence of cytotoxic helper ILCs that are distinct from conventional NK cells. In humans, these cytotoxic ILCs can develop from conventional helper ILCs whereas in mice this remains to be elucidated. In this review we discuss the identification, development and function of cytotoxic helper ILCs subsets in humans and mice.
UR - http://www.scopus.com/inward/record.url?scp=85091235461&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.coi.2020.08.007
DO - https://doi.org/10.1016/j.coi.2020.08.007
M3 - Review article
C2 - 32971468
SN - 0952-7915
VL - 68
SP - 28
EP - 33
JO - Current opinion in immunology
JF - Current opinion in immunology
ER -