Insulin-like growth factor 1 has multisystem effects on foetal and preterm infant development

Ann Hellström, David Ley, Ingrid Hansen-Pupp, Boubou Hallberg, Chatarina Löfqvist, Linda van Marter, Mirjam van Weissenbruch, Luca A Ramenghi, Kathryn Beardsall, David Dunger, Anna-Lena Hård, Lois E H Smith

Research output: Contribution to journalArticleAcademicpeer-review

125 Citations (Scopus)

Abstract

UNLABELLED: Poor postnatal growth after preterm birth does not match the normal rapid growth in utero and is associated with preterm morbidities. Insulin-like growth factor 1 (IGF-1) axis is the major hormonal mediator of growth in utero, and levels of IGF-1 are often very low after preterm birth. We reviewed the role of IGF-1 in foetal development and the corresponding preterm perinatal period to highlight the potential clinical importance of IGF-1 deficiency in preterm morbidities.

CONCLUSION: There is a rationale for clinical trials to evaluate the potential benefits of IGF-1 replacement in very preterm infants.

Original languageEnglish
Pages (from-to)576-86
Number of pages11
JournalActa Paediatrica
Volume105
Issue number6
DOIs
Publication statusPublished - Jun 2016

Keywords

  • Journal Article
  • Review

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