Intensive Blood Pressure Control Affects Cerebral Blood Flow in Type 2 Diabetes Mellitus Patients

Yu-Sok Kim, Shyrin C. A. T. Davis, Jasper Truijen, Wim J. Stok, Niels H. Secher, Johannes J. van Lieshout

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Type 2 diabetes mellitus is associated with microvascular complications, hypertension, and impaired dynamic cerebral autoregulation. Intensive blood pressure (BP) control in hypertensive type 2 diabetic patients reduces their risk of stroke but may affect cerebral perfusion. Systemic hemodynamic variables and transcranial Doppler-determined cerebral blood flow velocity (CBFV), cerebral CO2 responsiveness, and cognitive function were determined after 3 and 6 months of intensive BP control in 17 type 2 diabetic patients with microvascular complications (T2DM+), in 18 diabetic patients without (T2DM-) microvascular complications, and in 16 nondiabetic hypertensive patients. Cerebrovascular reserve capacity was lower in T2DM+ versus T2DM- and nondiabetic hypertensive patients (4.6 +/- 1.1 versus 6.0 +/- 1.6 [P <.05] and 6.6 +/- 1.7 [P <.01], Delta% mean CBFV/mm Hg). After 6 months, the attained BP was comparable among the 3 groups. However, in contrast to nondiabetic hypertensive patients, intensive BP control reduced CBFV in T2DM- (58 +/- 9 to 54 +/- 12 cm . s(-1)) and T2DM+ (57 +/- 13 to 52 +/- 11 cm . s(-1)) at 3 months, but CBFV returned to baseline at 6 months only in T2DM-, whereas the reduction in CBFV progressed in T2DM+ (to 48 +/- 8 cm . s(-1)). Cognitive function did not change during the 6 months. Static cerebrovascular autoregulation appears to be impaired in type 2 diabetes mellitus, with a transient reduction in CBFV in uncomplicated diabetic patients on tight BP control, but with a progressive reduction in CBFV in diabetic patients with microvascular complications, indicating that maintenance of cerebral perfusion during BP treatment depends on the progression of microvascular disease. We suggest that BP treatment should be individualized, aiming at a balance between BP reduction and maintenance of CBFV. (Hypertension. 2011;57:738-745.)
Original languageEnglish
Pages (from-to)738-+
Number of pages8
Issue number4
Publication statusPublished - Apr 2011


  • Adult
  • Aged
  • Analysis of Variance
  • Antihypertensive Agents/therapeutic use
  • Blood Flow Velocity/drug effects
  • Blood Pressure/drug effects
  • Cerebrovascular Circulation/drug effects
  • Cognition/drug effects
  • Diabetes Mellitus, Type 2/diagnostic imaging
  • Diabetic Angiopathies/diagnostic imaging
  • Female
  • Humans
  • Hypertension/diagnostic imaging
  • Male
  • Middle Aged
  • Patient Selection
  • Photoplethysmography
  • Ultrasonography, Doppler, Transcranial

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