TY - JOUR
T1 - Interaction between the FTO gene, body mass index and depression: meta-analysis of 13701 individuals
AU - Rivera, Margarita
AU - Locke, Adam E
AU - Corre, Tanguy
AU - Czamara, Darina
AU - Wolf, Christiane
AU - Ching-Lopez, Ana
AU - Milaneschi, Yuri
AU - Kloiber, Stefan
AU - Cohen-Woods, Sara
AU - Rucker, James
AU - Aitchison, Katherine J
AU - Bergmann, Sven
AU - Boomsma, Dorret I
AU - Craddock, Nick
AU - Gill, Michael
AU - Holsboer, Florian
AU - Hottenga, Jouke-Jan
AU - Korszun, Ania
AU - Kutalik, Zoltan
AU - Lucae, Susanne
AU - Maier, Wolfgang
AU - Mors, Ole
AU - Müller-Myhsok, Bertram
AU - Owen, Michael J
AU - Penninx, Brenda W J H
AU - Preisig, Martin
AU - Rice, John P
AU - Rietschel, Marcella
AU - Tozzi, Federica
AU - Uher, Rudolf
AU - Vollenweider, Peter
AU - Waeber, Gerard
AU - Willemsen, Gonneke
AU - Craig, Ian W
AU - Farmer, Anne E
AU - Lewis, Cathryn M
AU - Breen, Gerome
AU - McGuffin, Peter
AU - Mueller-Myhsok, Bertram
N1 - Published online by Cambridge University Press: 02 January 2018
PY - 2017/8
Y1 - 2017/8
N2 - BackgroundDepression and obesity are highly prevalent, and major impacts on public health frequently co-occur. Recently, we reported that having depression moderates the effect of the FTO gene, suggesting its implication in the association between depression and obesity.AimsTo confirm these findings by investigating the FTO polymorphism rs9939609 in new cohorts, and subsequently in a meta-analysis.MethodThe sample consists of 6902 individuals with depression and 6799 controls from three replication cohorts and two original discovery cohorts. Linear regression models were performed to test for association between rs9939609 and body mass index (BMI), and for the interaction between rs9939609 and depression status for an effect on BMI. Fixed and random effects meta-analyses were performed using METASOFT.ResultsIn the replication cohorts, we observed a significant interaction between FTO, BMI and depression with fixed effects meta-analysis (β = 0.12, P = 2.7 × l0(-4)) and with the Han/Eskin random effects method (P = 1.4 × 10(-7)) but not with traditional random effects (β = 0.1, P = 0.35). When combined with the discovery cohorts, random effects meta-analysis also supports the interaction (β = 0.12, P = 0.027) being highly significant based on the Han/Eskin model (P = 6.9 × 10(-8)). On average, carriers of the risk allele who have depression have a 2.2% higher BMI for each risk allele, over and above the main effect of FTOConclusionsThis meta-analysis provides additional support for a significant interaction between FTO, depression and BMI, indicating that depression increases the effect of FTO on BMI. The findings provide a useful starting point in understanding the biological mechanism involved in the association between obesity and depression.
AB - BackgroundDepression and obesity are highly prevalent, and major impacts on public health frequently co-occur. Recently, we reported that having depression moderates the effect of the FTO gene, suggesting its implication in the association between depression and obesity.AimsTo confirm these findings by investigating the FTO polymorphism rs9939609 in new cohorts, and subsequently in a meta-analysis.MethodThe sample consists of 6902 individuals with depression and 6799 controls from three replication cohorts and two original discovery cohorts. Linear regression models were performed to test for association between rs9939609 and body mass index (BMI), and for the interaction between rs9939609 and depression status for an effect on BMI. Fixed and random effects meta-analyses were performed using METASOFT.ResultsIn the replication cohorts, we observed a significant interaction between FTO, BMI and depression with fixed effects meta-analysis (β = 0.12, P = 2.7 × l0(-4)) and with the Han/Eskin random effects method (P = 1.4 × 10(-7)) but not with traditional random effects (β = 0.1, P = 0.35). When combined with the discovery cohorts, random effects meta-analysis also supports the interaction (β = 0.12, P = 0.027) being highly significant based on the Han/Eskin model (P = 6.9 × 10(-8)). On average, carriers of the risk allele who have depression have a 2.2% higher BMI for each risk allele, over and above the main effect of FTOConclusionsThis meta-analysis provides additional support for a significant interaction between FTO, depression and BMI, indicating that depression increases the effect of FTO on BMI. The findings provide a useful starting point in understanding the biological mechanism involved in the association between obesity and depression.
KW - Journal Article
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U2 - https://doi.org/10.1192/bjp.bp.116.183475
DO - https://doi.org/10.1192/bjp.bp.116.183475
M3 - Review article
C2 - 28642257
SN - 0007-1250
VL - 211
SP - 70
EP - 76
JO - British journal of psychiatry
JF - British journal of psychiatry
IS - 2
ER -
