Intercellular adhesion molecule-1 (ICAM-1) belongs to the superfamily of immunoglobulin-like adhesion molecules. Up-regulation of ICAM-1 occurs in many different pathophysiological processes. Also, cardiomyocytes can express ICAM-1-for example, in acute myocardial infarction. Moreover, inhibition of ICAM-1 expression in the heart dramatically reduces infarct size. Hence, inhibitors of ICAM-1 may provide a novel therapeutic option for acute myocardial infarction.

Original languageEnglish
Pages (from-to)573-85
Number of pages13
JournalAnnals of the New York Academy of Sciences
Publication statusPublished - Nov 2002


  • Animals
  • Cell Adhesion
  • Cell Line
  • Gene Expression Regulation
  • Heart
  • Humans
  • Intercellular Adhesion Molecule-1
  • Journal Article
  • Myocardial Infarction
  • Myocardium
  • Research Support, Non-U.S. Gov't
  • Review
  • Transcription Factors

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