Abstract
Intercellular adhesion molecule-1 (ICAM-1) belongs to the superfamily of immunoglobulin-like adhesion molecules. Up-regulation of ICAM-1 occurs in many different pathophysiological processes. Also, cardiomyocytes can express ICAM-1-for example, in acute myocardial infarction. Moreover, inhibition of ICAM-1 expression in the heart dramatically reduces infarct size. Hence, inhibitors of ICAM-1 may provide a novel therapeutic option for acute myocardial infarction.
Original language | English |
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Pages (from-to) | 573-85 |
Number of pages | 13 |
Journal | Annals of the New York Academy of Sciences |
Volume | 973 |
Publication status | Published - Nov 2002 |
Keywords
- Animals
- Cell Adhesion
- Cell Line
- Gene Expression Regulation
- Heart
- Humans
- Intercellular Adhesion Molecule-1
- Journal Article
- Myocardial Infarction
- Myocardium
- Research Support, Non-U.S. Gov't
- Review
- Transcription Factors