Interleukin-27: a potential new sepsis biomarker exposed through genome-wide transcriptional profiling

Brendon P. Scicluna; Tom van der Poll

doi:https://doi.org/10.1186/cc11893

Interleukin-27: a potential new sepsis biomarker exposed through genome-wide transcriptional profiling

Brendon P. Scicluna, Tom van der Poll

Research output: Contribution to journal › Editorial › Academic › peer-review

12 Citations (Scopus)

Abstract

Sepsis is a complex clinical condition that is driven predominantly by deviations from the orderly stereotypic immunological response to infection. Much effort has been undertaken in the search for biomarkers that can assist in discriminating critically ill patients with sterile inflammation from those with sepsis. Such biomarkers may aid the clinician in therapeutic decision making upon admission of a patient. Interleukin-27 may be such a discriminative biomarker, as suggested in the previous issue of Critical Care by a study of critically ill children

Original language	English
Pages (from-to)	188
Journal	Critical care (London, England)
Volume	16
Issue number	6
DOIs	https://doi.org/10.1186/cc11893
Publication status	Published - 2012

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https://doi.org/10.1186/cc11893

Cite this

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abstract = "Sepsis is a complex clinical condition that is driven predominantly by deviations from the orderly stereotypic immunological response to infection. Much effort has been undertaken in the search for biomarkers that can assist in discriminating critically ill patients with sterile inflammation from those with sepsis. Such biomarkers may aid the clinician in therapeutic decision making upon admission of a patient. Interleukin-27 may be such a discriminative biomarker, as suggested in the previous issue of Critical Care by a study of critically ill children",

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