Interleukins are defined as polypeptide hormones produced by a variety of cells of the immune system that act as soluble mediators in immunological and inflammatory reactions. Data of recent studies suggest that interleukins can affect the neurophysiology of the brain. For instance, IL-1 receptors are abundantly present in the brain and IL-1 mRNA and protein is expressed in neurons and glial cells. Although the function of neuronal IL-1 is not known, glial-derived IL-1 appears to be an essential component in tissue modulation after brain injury and during neurodegeneration such as occurring in Alzheimer's disease.
- Alzheimer's disease
- Brain injury
- Effects on brain physiology
- Localization in neurons and glial