Interleukins in the brain

F. Berkenbosch; A. van Dam

doi:https://doi.org/10.1016/0924-977X(91)90575-F

Interleukins in the brain

F. Berkenbosch, A. van Dam

Research output: Contribution to journal › Article › Academic › peer-review

1 Citation (Scopus)

Abstract

Interleukins are defined as polypeptide hormones produced by a variety of cells of the immune system that act as soluble mediators in immunological and inflammatory reactions. Data of recent studies suggest that interleukins can affect the neurophysiology of the brain. For instance, IL-1 receptors are abundantly present in the brain and IL-1 mRNA and protein is expressed in neurons and glial cells. Although the function of neuronal IL-1 is not known, glial-derived IL-1 appears to be an essential component in tissue modulation after brain injury and during neurodegeneration such as occurring in Alzheimer's disease.

Original language	English
Pages (from-to)	374-376
Number of pages	3
Journal	European neuropsychopharmacology
Volume	1
Issue number	3
DOIs	https://doi.org/10.1016/0924-977X(91)90575-F
Publication status	Published - Sept 1991

Keywords

Alzheimer's disease
Brain injury
Effects on brain physiology
Interleukin-1
Localization in neurons and glial

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https://doi.org/10.1016/0924-977X(91)90575-F

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AB - Interleukins are defined as polypeptide hormones produced by a variety of cells of the immune system that act as soluble mediators in immunological and inflammatory reactions. Data of recent studies suggest that interleukins can affect the neurophysiology of the brain. For instance, IL-1 receptors are abundantly present in the brain and IL-1 mRNA and protein is expressed in neurons and glial cells. Although the function of neuronal IL-1 is not known, glial-derived IL-1 appears to be an essential component in tissue modulation after brain injury and during neurodegeneration such as occurring in Alzheimer's disease.

KW - Alzheimer's disease

KW - Brain injury

KW - Effects on brain physiology

KW - Interleukin-1

KW - Localization in neurons and glial

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JO - European neuropsychopharmacology

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Interleukins in the brain

Abstract

Keywords

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