International Consensus Recommendations for Eosinophilic Gastrointestinal Disease Nomenclature

Evan S. Dellon; Nirmala Gonsalves; J. Pablo Abonia; Jeffrey A. Alexander; Nicoleta C. Arva; Dan Atkins; Stephen E. Attwood; Marcus K. H. Auth; Dominique D. Bailey; Luc Biederman; Carine Blanchard; Peter A. Bonis; Paroma Bose; Albert J. Bredenoord; Joy W. Chang; Mirna Chehade; Margaret H. Collins; Carlo di Lorenzo; Jorge Amil Dias; Ranjan Dohil; Christophe Dupont; Gary W. Falk; Cristina T. Ferreira; Adam T. Fox; Robert M. Genta; Thomas Greuter; Sandeep K. Gupta; Ikuo Hirano; Girish S. Hiremath; Jennifer L. Horsley-Silva; Shunji Ishihara; Norihisa Ishimura; Elizabeth T. Jensen; Carolina Gutiérrez-Junquera; David A. Katzka; Paneez Khoury; Yoshikazu Kinoshita; Kara L. Kliewer; Sibylle Koletzko; John Leung; Chris A. Liacouras; Alfredo J. Lucendo; Lisa J. Martin; Emily C. McGowan; Calies Menard-Katcher; David C. Metz; Talya L. Miller; Fouad J. Moawad; Amanda B. Muir; Vincent A. Mukkada; Simon Murch; Quan M. Nhu; Ichiro Nomura; Samuel Nurko; Yoshikazu Ohtsuka; Salvatore Oliva; Rok Orel; Alexandra Papadopoulou; Dhyanesh A. Patel; Robert D. Pesek; Kathryn A. Peterson; Hamish Philpott; Philip E. Putnam; Joel E. Richter; Rachel Rosen; Melanie A. Ruffner; Ekaterina Safroneeva; Philipp Schreiner; Alain Schoepfer; Shauna R. Schroeder; Neil Shah; Rhonda F. Souza; Stuart J. Spechler; Jonathan M. Spergel; Alex Straumann; Nicholas J. Talley; Nikhil Thapar; Yvan Vandenplas; Rajitha D. Venkatesh; Mario C. Vieira; Ulrike von Arnim; Marjorie M. Walker; Joshua B. Wechsler; Barry K. Wershil; Benjamin L. Wright; Yoshiyuki Yamada; Guang-Yu Yang; Noam Zevit; Marc E. Rothenberg; Glenn T. Furuta; Seema S. Aceves

doi:https://doi.org/10.1016/j.cgh.2022.02.017

International Consensus Recommendations for Eosinophilic Gastrointestinal Disease Nomenclature

Evan S. Dellon, Nirmala Gonsalves, J. Pablo Abonia, Jeffrey A. Alexander, Nicoleta C. Arva, Dan Atkins, Stephen E. Attwood, Marcus K. H. Auth, Dominique D. Bailey, Luc Biederman, Carine Blanchard, Peter A. Bonis, Paroma Bose, Albert J. Bredenoord, Joy W. Chang, Mirna Chehade, Margaret H. Collins, Carlo di Lorenzo, Jorge Amil Dias, Ranjan DohilChristophe Dupont, Gary W. Falk, Cristina T. Ferreira, Adam T. Fox, Robert M. Genta, Thomas Greuter, Sandeep K. Gupta, Ikuo Hirano, Girish S. Hiremath, Jennifer L. Horsley-Silva, Shunji Ishihara, Norihisa Ishimura, Elizabeth T. Jensen, Carolina Gutiérrez-Junquera, David A. Katzka, Paneez Khoury, Yoshikazu Kinoshita, Kara L. Kliewer, Sibylle Koletzko, John Leung, Chris A. Liacouras, Alfredo J. Lucendo, Lisa J. Martin, Emily C. McGowan, Calies Menard-Katcher, David C. Metz, Talya L. Miller, Fouad J. Moawad, Amanda B. Muir, Vincent A. Mukkada, Simon Murch, Quan M. Nhu, Ichiro Nomura, Samuel Nurko, Yoshikazu Ohtsuka, Salvatore Oliva, Rok Orel, Alexandra Papadopoulou, Dhyanesh A. Patel, Robert D. Pesek, Kathryn A. Peterson, Hamish Philpott, Philip E. Putnam, Joel E. Richter, Rachel Rosen, Melanie A. Ruffner, Ekaterina Safroneeva, Philipp Schreiner, Alain Schoepfer, Shauna R. Schroeder, Neil Shah, Rhonda F. Souza, Stuart J. Spechler, Jonathan M. Spergel, Alex Straumann, Nicholas J. Talley, Nikhil Thapar, Yvan Vandenplas, Rajitha D. Venkatesh, Mario C. Vieira, Ulrike von Arnim, Marjorie M. Walker, Joshua B. Wechsler, Barry K. Wershil, Benjamin L. Wright, Yoshiyuki Yamada, Guang-Yu Yang, Noam Zevit, Marc E. Rothenberg, Glenn T. Furuta, Seema S. Aceves

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Background & Aims: Substantial heterogeneity in terminology used for eosinophilic gastrointestinal diseases (EGIDs), particularly the catchall term “eosinophilic gastroenteritis,” limits clinical and research advances. We aimed to achieve an international consensus for standardized EGID nomenclature. Methods: This consensus process utilized Delphi methodology. An initial naming framework was proposed and refined in iterative fashion, then assessed in a first round of Delphi voting. Results were discussed in 2 consensus meetings, and the framework was updated and reassessed in a second Delphi vote, with a 70% threshold set for agreement. Results: Of 91 experts participating, 85 (93%) completed the first and 82 (90%) completed the second Delphi surveys. Consensus was reached on all but 2 statements. “EGID” was the preferred umbrella term for disorders of gastrointestinal (GI) tract eosinophilic inflammation in the absence of secondary causes (100% agreement). Involved GI tract segments will be named specifically and use an “Eo” abbreviation convention: eosinophilic gastritis (now abbreviated EoG), eosinophilic enteritis (EoN), and eosinophilic colitis (EoC). The term “eosinophilic gastroenteritis” is no longer preferred as the overall name (96% agreement). When >2 GI tract areas are involved, the name should reflect all of the involved areas. Conclusions: This international process resulted in consensus for updated EGID nomenclature for both clinical and research use. EGID will be the umbrella term, rather than “eosinophilic gastroenteritis,” and specific naming conventions by location of GI tract involvement are recommended. As more data are developed, this framework can be updated to reflect best practices and the underlying science.

Original language	English
Pages (from-to)	2474-2484.e3
Journal	Clinical Gastroenterology and Hepatology
Volume	20
Issue number	11
Early online date	2022
DOIs	https://doi.org/10.1016/j.cgh.2022.02.017
Publication status	Published - Nov 2022

Keywords

Classification
Delphi
Eosinophilic Gastroenteritis
Eosinophilic Gastrointestinal Disease
Nomenclature

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https://doi.org/10.1016/j.cgh.2022.02.017

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Dellon, E. S., Gonsalves, N., Abonia, J. P., Alexander, J. A., Arva, N. C., Atkins, D., Attwood, S. E., Auth, M. K. H., Bailey, D. D., Biederman, L., Blanchard, C., Bonis, P. A., Bose, P., Bredenoord, A. J., Chang, J. W., Chehade, M., Collins, M. H., di Lorenzo, C., Dias, J. A., ... Aceves, S. S. (2022). International Consensus Recommendations for Eosinophilic Gastrointestinal Disease Nomenclature. Clinical Gastroenterology and Hepatology, 20(11), 2474-2484.e3. https://doi.org/10.1016/j.cgh.2022.02.017

@article{41a53549aa4c4da59c867bef89762c87,

title = "International Consensus Recommendations for Eosinophilic Gastrointestinal Disease Nomenclature",

abstract = "Background & Aims: Substantial heterogeneity in terminology used for eosinophilic gastrointestinal diseases (EGIDs), particularly the catchall term “eosinophilic gastroenteritis,” limits clinical and research advances. We aimed to achieve an international consensus for standardized EGID nomenclature. Methods: This consensus process utilized Delphi methodology. An initial naming framework was proposed and refined in iterative fashion, then assessed in a first round of Delphi voting. Results were discussed in 2 consensus meetings, and the framework was updated and reassessed in a second Delphi vote, with a 70% threshold set for agreement. Results: Of 91 experts participating, 85 (93%) completed the first and 82 (90%) completed the second Delphi surveys. Consensus was reached on all but 2 statements. “EGID” was the preferred umbrella term for disorders of gastrointestinal (GI) tract eosinophilic inflammation in the absence of secondary causes (100% agreement). Involved GI tract segments will be named specifically and use an “Eo” abbreviation convention: eosinophilic gastritis (now abbreviated EoG), eosinophilic enteritis (EoN), and eosinophilic colitis (EoC). The term “eosinophilic gastroenteritis” is no longer preferred as the overall name (96% agreement). When >2 GI tract areas are involved, the name should reflect all of the involved areas. Conclusions: This international process resulted in consensus for updated EGID nomenclature for both clinical and research use. EGID will be the umbrella term, rather than “eosinophilic gastroenteritis,” and specific naming conventions by location of GI tract involvement are recommended. As more data are developed, this framework can be updated to reflect best practices and the underlying science.",

keywords = "Classification, Delphi, Eosinophilic Gastroenteritis, Eosinophilic Gastrointestinal Disease, Nomenclature",

author = "Dellon, {Evan S.} and Nirmala Gonsalves and Abonia, {J. Pablo} and Alexander, {Jeffrey A.} and Arva, {Nicoleta C.} and Dan Atkins and Attwood, {Stephen E.} and Auth, {Marcus K. H.} and Bailey, {Dominique D.} and Luc Biederman and Carine Blanchard and Bonis, {Peter A.} and Paroma Bose and Bredenoord, {Albert J.} and Chang, {Joy W.} and Mirna Chehade and Collins, {Margaret H.} and {di Lorenzo}, Carlo and Dias, {Jorge Amil} and Ranjan Dohil and Christophe Dupont and Falk, {Gary W.} and Ferreira, {Cristina T.} and Fox, {Adam T.} and Genta, {Robert M.} and Thomas Greuter and Gupta, {Sandeep K.} and Ikuo Hirano and Hiremath, {Girish S.} and Horsley-Silva, {Jennifer L.} and Shunji Ishihara and Norihisa Ishimura and Jensen, {Elizabeth T.} and Carolina Guti{\'e}rrez-Junquera and Katzka, {David A.} and Paneez Khoury and Yoshikazu Kinoshita and Kliewer, {Kara L.} and Sibylle Koletzko and John Leung and Liacouras, {Chris A.} and Lucendo, {Alfredo J.} and Martin, {Lisa J.} and McGowan, {Emily C.} and Calies Menard-Katcher and Metz, {David C.} and Miller, {Talya L.} and Moawad, {Fouad J.} and Muir, {Amanda B.} and Mukkada, {Vincent A.} and Simon Murch and Nhu, {Quan M.} and Ichiro Nomura and Samuel Nurko and Yoshikazu Ohtsuka and Salvatore Oliva and Rok Orel and Alexandra Papadopoulou and Patel, {Dhyanesh A.} and Pesek, {Robert D.} and Peterson, {Kathryn A.} and Hamish Philpott and Putnam, {Philip E.} and Richter, {Joel E.} and Rachel Rosen and Ruffner, {Melanie A.} and Ekaterina Safroneeva and Philipp Schreiner and Alain Schoepfer and Schroeder, {Shauna R.} and Neil Shah and Souza, {Rhonda F.} and Spechler, {Stuart J.} and Spergel, {Jonathan M.} and Alex Straumann and Talley, {Nicholas J.} and Nikhil Thapar and Yvan Vandenplas and Venkatesh, {Rajitha D.} and Vieira, {Mario C.} and {von Arnim}, Ulrike and Walker, {Marjorie M.} and Wechsler, {Joshua B.} and Wershil, {Barry K.} and Wright, {Benjamin L.} and Yoshiyuki Yamada and Guang-Yu Yang and Noam Zevit and Rothenberg, {Marc E.} and Furuta, {Glenn T.} and Aceves, {Seema S.}",

note = "Funding Information: Funding The Consortium of Eosinophilic Gastrointestinal Disease Researcheres (CEGIR) (U54 AI117804) is part of the Rare Disease Clinical Research Network, an initiative of the Office of Rare Diseases Research, NCATS, and is funded through collaboration between National Institute of Allergy and Infectious Diseases, United States, National Institute on Diabetes and Digestive and Kidney Diseases, and National Center for Advancing Translational Sciences, United States. CEGIR is also supported by patient advocacy groups including American Partnership for Eosinophilic Disorders, United States, Campaign Urging Research for Eosinophilic Diseases, United States, and Eosinophilic Family Coalition. As a member of the Rare Disease Clinical Research Network, CEGIR is also supported by its Data Management and Coordinating Center (U2CTR002818). Funding Information: The authors gratefully acknowledge the input and review from the following patient advocacy groups and their representatives: the American Partnership for Eosinophilic Disorders (Mary Jo Strobel), AusEE (Sarah Gray), the Campaign Urging Research for Eosinophilic Disease (Ellyn Kodroff), the Eosinophilic Family Coalition (Amy Zicarelli), and EosNetwork (Amanda Cordell). They also thank Rhona Jackson for her administrative assistance in coordinating this process and manuscript submission. Publisher Copyright: {\textcopyright} 2022",

year = "2022",

month = nov,

doi = "https://doi.org/10.1016/j.cgh.2022.02.017",

language = "English",

volume = "20",

pages = "2474--2484.e3",

journal = "Clinical Gastroenterology and Hepatology",

issn = "1542-3565",

publisher = "W.B. Saunders Ltd",

number = "11",

}

Dellon, ES, Gonsalves, N, Abonia, JP, Alexander, JA, Arva, NC, Atkins, D, Attwood, SE, Auth, MKH, Bailey, DD, Biederman, L, Blanchard, C, Bonis, PA, Bose, P, Bredenoord, AJ, Chang, JW, Chehade, M, Collins, MH, di Lorenzo, C, Dias, JA, Dohil, R, Dupont, C, Falk, GW, Ferreira, CT, Fox, AT, Genta, RM, Greuter, T, Gupta, SK, Hirano, I, Hiremath, GS, Horsley-Silva, JL, Ishihara, S, Ishimura, N, Jensen, ET, Gutiérrez-Junquera, C, Katzka, DA, Khoury, P, Kinoshita, Y, Kliewer, KL, Koletzko, S, Leung, J, Liacouras, CA, Lucendo, AJ, Martin, LJ, McGowan, EC, Menard-Katcher, C, Metz, DC, Miller, TL, Moawad, FJ, Muir, AB, Mukkada, VA, Murch, S, Nhu, QM, Nomura, I, Nurko, S, Ohtsuka, Y, Oliva, S, Orel, R, Papadopoulou, A, Patel, DA, Pesek, RD, Peterson, KA, Philpott, H, Putnam, PE, Richter, JE, Rosen, R, Ruffner, MA, Safroneeva, E, Schreiner, P, Schoepfer, A, Schroeder, SR, Shah, N, Souza, RF, Spechler, SJ, Spergel, JM, Straumann, A, Talley, NJ, Thapar, N, Vandenplas, Y, Venkatesh, RD, Vieira, MC, von Arnim, U, Walker, MM, Wechsler, JB, Wershil, BK, Wright, BL, Yamada, Y, Yang, G-Y, Zevit, N, Rothenberg, ME, Furuta, GT & Aceves, SS 2022, 'International Consensus Recommendations for Eosinophilic Gastrointestinal Disease Nomenclature', Clinical Gastroenterology and Hepatology, vol. 20, no. 11, pp. 2474-2484.e3. https://doi.org/10.1016/j.cgh.2022.02.017

TY - JOUR

T1 - International Consensus Recommendations for Eosinophilic Gastrointestinal Disease Nomenclature

AU - Dellon, Evan S.

AU - Gonsalves, Nirmala

AU - Abonia, J. Pablo

AU - Alexander, Jeffrey A.

AU - Arva, Nicoleta C.

AU - Atkins, Dan

AU - Attwood, Stephen E.

AU - Auth, Marcus K. H.

AU - Bailey, Dominique D.

AU - Biederman, Luc

AU - Blanchard, Carine

AU - Bonis, Peter A.

AU - Bose, Paroma

AU - Bredenoord, Albert J.

AU - Chang, Joy W.

AU - Chehade, Mirna

AU - Collins, Margaret H.

AU - di Lorenzo, Carlo

AU - Dias, Jorge Amil

AU - Dohil, Ranjan

AU - Dupont, Christophe

AU - Falk, Gary W.

AU - Ferreira, Cristina T.

AU - Fox, Adam T.

AU - Genta, Robert M.

AU - Greuter, Thomas

AU - Gupta, Sandeep K.

AU - Hirano, Ikuo

AU - Hiremath, Girish S.

AU - Horsley-Silva, Jennifer L.

AU - Ishihara, Shunji

AU - Ishimura, Norihisa

AU - Jensen, Elizabeth T.

AU - Gutiérrez-Junquera, Carolina

AU - Katzka, David A.

AU - Khoury, Paneez

AU - Kinoshita, Yoshikazu

AU - Kliewer, Kara L.

AU - Koletzko, Sibylle

AU - Leung, John

AU - Liacouras, Chris A.

AU - Lucendo, Alfredo J.

AU - Martin, Lisa J.

AU - McGowan, Emily C.

AU - Menard-Katcher, Calies

AU - Metz, David C.

AU - Miller, Talya L.

AU - Moawad, Fouad J.

AU - Muir, Amanda B.

AU - Mukkada, Vincent A.

AU - Murch, Simon

AU - Nhu, Quan M.

AU - Nomura, Ichiro

AU - Nurko, Samuel

AU - Ohtsuka, Yoshikazu

AU - Oliva, Salvatore

AU - Orel, Rok

AU - Papadopoulou, Alexandra

AU - Patel, Dhyanesh A.

AU - Pesek, Robert D.

AU - Peterson, Kathryn A.

AU - Philpott, Hamish

AU - Putnam, Philip E.

AU - Richter, Joel E.

AU - Rosen, Rachel

AU - Ruffner, Melanie A.

AU - Safroneeva, Ekaterina

AU - Schreiner, Philipp

AU - Schoepfer, Alain

AU - Schroeder, Shauna R.

AU - Shah, Neil

AU - Souza, Rhonda F.

AU - Spechler, Stuart J.

AU - Spergel, Jonathan M.

AU - Straumann, Alex

AU - Talley, Nicholas J.

AU - Thapar, Nikhil

AU - Vandenplas, Yvan

AU - Venkatesh, Rajitha D.

AU - Vieira, Mario C.

AU - von Arnim, Ulrike

AU - Walker, Marjorie M.

AU - Wechsler, Joshua B.

AU - Wershil, Barry K.

AU - Wright, Benjamin L.

AU - Yamada, Yoshiyuki

AU - Yang, Guang-Yu

AU - Zevit, Noam

AU - Rothenberg, Marc E.

AU - Furuta, Glenn T.

AU - Aceves, Seema S.

N1 - Funding Information: Funding The Consortium of Eosinophilic Gastrointestinal Disease Researcheres (CEGIR) (U54 AI117804) is part of the Rare Disease Clinical Research Network, an initiative of the Office of Rare Diseases Research, NCATS, and is funded through collaboration between National Institute of Allergy and Infectious Diseases, United States, National Institute on Diabetes and Digestive and Kidney Diseases, and National Center for Advancing Translational Sciences, United States. CEGIR is also supported by patient advocacy groups including American Partnership for Eosinophilic Disorders, United States, Campaign Urging Research for Eosinophilic Diseases, United States, and Eosinophilic Family Coalition. As a member of the Rare Disease Clinical Research Network, CEGIR is also supported by its Data Management and Coordinating Center (U2CTR002818). Funding Information: The authors gratefully acknowledge the input and review from the following patient advocacy groups and their representatives: the American Partnership for Eosinophilic Disorders (Mary Jo Strobel), AusEE (Sarah Gray), the Campaign Urging Research for Eosinophilic Disease (Ellyn Kodroff), the Eosinophilic Family Coalition (Amy Zicarelli), and EosNetwork (Amanda Cordell). They also thank Rhona Jackson for her administrative assistance in coordinating this process and manuscript submission. Publisher Copyright: © 2022

PY - 2022/11

Y1 - 2022/11

N2 - Background & Aims: Substantial heterogeneity in terminology used for eosinophilic gastrointestinal diseases (EGIDs), particularly the catchall term “eosinophilic gastroenteritis,” limits clinical and research advances. We aimed to achieve an international consensus for standardized EGID nomenclature. Methods: This consensus process utilized Delphi methodology. An initial naming framework was proposed and refined in iterative fashion, then assessed in a first round of Delphi voting. Results were discussed in 2 consensus meetings, and the framework was updated and reassessed in a second Delphi vote, with a 70% threshold set for agreement. Results: Of 91 experts participating, 85 (93%) completed the first and 82 (90%) completed the second Delphi surveys. Consensus was reached on all but 2 statements. “EGID” was the preferred umbrella term for disorders of gastrointestinal (GI) tract eosinophilic inflammation in the absence of secondary causes (100% agreement). Involved GI tract segments will be named specifically and use an “Eo” abbreviation convention: eosinophilic gastritis (now abbreviated EoG), eosinophilic enteritis (EoN), and eosinophilic colitis (EoC). The term “eosinophilic gastroenteritis” is no longer preferred as the overall name (96% agreement). When >2 GI tract areas are involved, the name should reflect all of the involved areas. Conclusions: This international process resulted in consensus for updated EGID nomenclature for both clinical and research use. EGID will be the umbrella term, rather than “eosinophilic gastroenteritis,” and specific naming conventions by location of GI tract involvement are recommended. As more data are developed, this framework can be updated to reflect best practices and the underlying science.

AB - Background & Aims: Substantial heterogeneity in terminology used for eosinophilic gastrointestinal diseases (EGIDs), particularly the catchall term “eosinophilic gastroenteritis,” limits clinical and research advances. We aimed to achieve an international consensus for standardized EGID nomenclature. Methods: This consensus process utilized Delphi methodology. An initial naming framework was proposed and refined in iterative fashion, then assessed in a first round of Delphi voting. Results were discussed in 2 consensus meetings, and the framework was updated and reassessed in a second Delphi vote, with a 70% threshold set for agreement. Results: Of 91 experts participating, 85 (93%) completed the first and 82 (90%) completed the second Delphi surveys. Consensus was reached on all but 2 statements. “EGID” was the preferred umbrella term for disorders of gastrointestinal (GI) tract eosinophilic inflammation in the absence of secondary causes (100% agreement). Involved GI tract segments will be named specifically and use an “Eo” abbreviation convention: eosinophilic gastritis (now abbreviated EoG), eosinophilic enteritis (EoN), and eosinophilic colitis (EoC). The term “eosinophilic gastroenteritis” is no longer preferred as the overall name (96% agreement). When >2 GI tract areas are involved, the name should reflect all of the involved areas. Conclusions: This international process resulted in consensus for updated EGID nomenclature for both clinical and research use. EGID will be the umbrella term, rather than “eosinophilic gastroenteritis,” and specific naming conventions by location of GI tract involvement are recommended. As more data are developed, this framework can be updated to reflect best practices and the underlying science.

KW - Classification

KW - Delphi

KW - Eosinophilic Gastroenteritis

KW - Eosinophilic Gastrointestinal Disease

KW - Nomenclature

UR - http://www.scopus.com/inward/record.url?scp=85125528185&partnerID=8YFLogxK

U2 - https://doi.org/10.1016/j.cgh.2022.02.017

DO - https://doi.org/10.1016/j.cgh.2022.02.017

M3 - Article

C2 - 35181570

SN - 1542-3565

VL - 20

SP - 2474-2484.e3

JO - Clinical Gastroenterology and Hepatology

JF - Clinical Gastroenterology and Hepatology

IS - 11

ER -

International Consensus Recommendations for Eosinophilic Gastrointestinal Disease Nomenclature

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