Interplay between genetic risk and the parent environment in adolescence and substance use in young adulthood: A TRAILS study

Joëlle A. Pasman, Koen Smit, Wilma A.M. Vollebergh, Ilja M. Nolte, Catharina A. Hartman, Abdel Abdellaoui, Karin J.H. Verweij, Dominique MacIejewski, Jacqueline M. Vink

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Abstract

Many adolescents start using tobacco, alcohol, and cannabis. Genetic vulnerability, parent characteristics in young adolescence, and interaction (GxE) and correlation (rGE) between these factors could contribute to the development of substance use. Using prospective data from the TRacking Adolescent Individuals' Lives Survey (TRAILS; N = 1,645), we model latent parent characteristics in young adolescence to predict young adult substance use. Polygenic scores (PGS) are created based on genome-wide association studies (GWAS) for smoking, alcohol use, and cannabis use. Using structural equation modeling we model the direct, GxE, and rGE effects of parent factors and PGS on young adult smoking, alcohol use, and cannabis initiation. The PGS, parental involvement, parental substance use, and parent-child relationship quality predicted smoking. There was GxE such that the PGS amplified the effect of parental substance use on smoking. There was rGE between all parent factors and the smoking PGS. Alcohol use was not predicted by genetic or parent factors, nor by interplay. Cannabis initiation was predicted by the PGS and parental substance use, but there was no GxE or rGE. Genetic risk and parent factors are important predictors of substance use and show GxE and rGE in smoking. These findings can act as a starting point for identifying people at risk.

Original languageEnglish
Pages (from-to)396-409
Number of pages14
JournalDevelopment and psychopathology
Volume35
Issue number1
Early online date2021
DOIs
Publication statusPublished - 28 Feb 2023

Keywords

  • Gene×Environment interaction
  • genetic nurturing
  • parenting
  • smoking
  • substance use

Cite this