@article{e25cc989c2684cb4856be44eac9c816c,
title = "Intestinal stem cell dynamics in homeostasis and cancer",
abstract = "The relationship between intestinal stem cells (ISCs) and colorectal cancer (CRC) has been a topic of intense study. Uncovering stem cell dynamics in homeostasis and following acquisition of oncogenic mutations has provided unprecedented insights into CRC initiation, and it is increasingly evident that the microenvironment plays a key role in regulating stem cell fate and functionality. Consequently, imbalances in the signaling between the niche and ISCs perturb homeostasis and promote cancer development. Furthermore, stem cell-like cells drive growth and progression of established CRCs and these cells also critically rely on microenvironmental input. Here, we highlight the importance of stem cell/niche interactions in developing and established CRC and discuss how these can be modulated to develop novel preventive and therapeutic interventions.",
keywords = "cell competition, colorectal cancer, intestinal stem cells, microenvironment, mutations, stem cell niche",
author = "Rana Ramadan and {van Driel}, {Milou S.} and Louis Vermeulen and {van Neerven}, {Sanne M.}",
note = "Funding Information: This work is supported by The New York Stem Cell Foundation and grants from KWF Dutch Cancer Society (UVA2014-7245), the Maurits en Anna de Kock Stichting (2015-2), Worldwide Cancer Research (14-1164), the Maag Lever Darm Stichting (MLDS-CDG 14-03), the European Research Council (ERG-StG 638193), and ZonMw (Vidi 016.156.308) to L.V. L.V. is a New York Stem Cell Foundation?Robertson Investigator. S.M.v.N. is supported by the ?AGEM? Innovation grant (2021), the ?Maurits en Anna de Kock Stichting? (2021-9), and a NWO OOA PhD scholarship (022.005.002). L.V. received consultancy fees from Bayer, MSD, Genentech, Servier, and Pierre Fabre, but these had no relation to the content of this publication. Funding Information: This work is supported by The New York Stem Cell Foundation and grants from KWF Dutch Cancer Society ( UVA2014-7245 ), the Maurits en Anna de Kock Stichting ( 2015-2 ), Worldwide Cancer Research ( 14-1164 ), the Maag Lever Darm Stichting ( MLDS-CDG 14-03 ), the European Research Council ( ERG-StG 638193 ), and ZonMw (Vidi 016.156.308 ) to L.V. L.V. is a New York Stem Cell Foundation –Robertson Investigator. S.M.v.N. is supported by the {\textquoteleft}AGEM{\textquoteright} Innovation grant ( 2021 ), the {\textquoteleft}Maurits en Anna de Kock Stichting{\textquoteright} ( 2021-9 ), and a NWO OOA PhD scholarship ( 022.005.002 ). Publisher Copyright: {\textcopyright} 2022 The Author(s)",
year = "2022",
month = may,
doi = "https://doi.org/10.1016/j.trecan.2022.01.011",
language = "English",
volume = "8",
pages = "416--425",
journal = "Trends in Cancer",
issn = "2405-8033",
publisher = "Cell Press",
number = "5",
}