TY - JOUR
T1 - Introduction of hypothermia for neonates with perinatal asphyxia in the Netherlands and flanders
AU - Groenendaal, Floris
AU - Casaer, Alexandra
AU - Dijkman, Koen P.
AU - Gavilanes, Antonio W. D.
AU - de Haan, Timo R.
AU - ter Horst, Henk J.
AU - Laroche, Sabine
AU - Naulaers, Gunnar
AU - Rijken, Monique
AU - van Straaten, Henrica L. M.
AU - Steiner, Katerina
AU - Swarte, Renate M. C.
AU - Zecic, Alexandra
AU - Zonnenberg, Inge A.
PY - 2013
Y1 - 2013
N2 - Background: Therapeutic hypothermia was introduced in the Netherlands and Flanders, Belgium, in 2008. Since then, an increasing number of patients has been treated - up to 166 in 2010. Complications and outcome were registered in an online database. Objectives: The aim of this study was to analyse complications and outcome after implementation. Methods: Data were retrieved from an online database to which all centres had contributed. Results: In 3 years, 332 patients were treated. Excluding 24 patients with congenital abnormalities or metabolic disorders, mortality was 31.8%. Of the 210 survivors without congenital malformations, 21 had cerebral palsy, another 19 a developmental delay of more than 3 months at the age of at least 24 months, and 2 had severe hearing loss. The total adverse outcome, combining death and adverse neurodevelopment, in 308 patients without congenital malformations is 45.5%, which is similar to that of the large trials. Conclusions: The introduction of therapeutic hypothermia for neonates with perinatal asphyxia in the Netherlands and Flanders has been rapid and successful, with results similar to findings in the randomised controlled trials
AB - Background: Therapeutic hypothermia was introduced in the Netherlands and Flanders, Belgium, in 2008. Since then, an increasing number of patients has been treated - up to 166 in 2010. Complications and outcome were registered in an online database. Objectives: The aim of this study was to analyse complications and outcome after implementation. Methods: Data were retrieved from an online database to which all centres had contributed. Results: In 3 years, 332 patients were treated. Excluding 24 patients with congenital abnormalities or metabolic disorders, mortality was 31.8%. Of the 210 survivors without congenital malformations, 21 had cerebral palsy, another 19 a developmental delay of more than 3 months at the age of at least 24 months, and 2 had severe hearing loss. The total adverse outcome, combining death and adverse neurodevelopment, in 308 patients without congenital malformations is 45.5%, which is similar to that of the large trials. Conclusions: The introduction of therapeutic hypothermia for neonates with perinatal asphyxia in the Netherlands and Flanders has been rapid and successful, with results similar to findings in the randomised controlled trials
U2 - https://doi.org/10.1159/000348823
DO - https://doi.org/10.1159/000348823
M3 - Article
C2 - 23615314
SN - 1661-7800
VL - 104
SP - 15
EP - 21
JO - Neonatology
JF - Neonatology
IS - 1
ER -