TY - JOUR
T1 - Invasive pneumococcal disease and 7-valent pneumococcal conjugate vaccine, the Netherlands
AU - van Deursen, Anna M. M.
AU - van Mens, Suzan P.
AU - Sanders, Elisabeth A. M.
AU - Vlaminckx, Bart J. M.
AU - de Melker, Hester E.
AU - Schouls, Leo M.
AU - de Greeff, Sabine C.
AU - van der Ende, Arie
PY - 2012
Y1 - 2012
N2 - In the Netherlands, the national immunization program includes 7-valent pneumococcal conjugate vaccine (PCV7) for all newborns born after April 1, 2006. We compared the incidence of invasive pneumococcal disease (IPD) and patient and disease characteristics before PCV7 introduction (June 2004-June 2006) with those after PCV7 introduction (June 2008-June 2010). Culture-confirmed IPD cases were identified by 9 sentinel laboratories covering ≈25% of the Dutch population. Significant declines in overall IPD incidence were observed in children <2 (60%) and in persons >65 (13%) years of age. A trend toward gradual increases in non-PCV7 serotype IPD infections was observed in all age groups; the largest increases were among persons 50-64 (37%) and >65 (25%) years of age. In adults, the proportion of immunocompromised persons increased among IPD patients. Overall, deaths from IPD decreased from 16% to 12% because of a lower case-fatality rate for persons with non-PCV7 serotype IPD
AB - In the Netherlands, the national immunization program includes 7-valent pneumococcal conjugate vaccine (PCV7) for all newborns born after April 1, 2006. We compared the incidence of invasive pneumococcal disease (IPD) and patient and disease characteristics before PCV7 introduction (June 2004-June 2006) with those after PCV7 introduction (June 2008-June 2010). Culture-confirmed IPD cases were identified by 9 sentinel laboratories covering ≈25% of the Dutch population. Significant declines in overall IPD incidence were observed in children <2 (60%) and in persons >65 (13%) years of age. A trend toward gradual increases in non-PCV7 serotype IPD infections was observed in all age groups; the largest increases were among persons 50-64 (37%) and >65 (25%) years of age. In adults, the proportion of immunocompromised persons increased among IPD patients. Overall, deaths from IPD decreased from 16% to 12% because of a lower case-fatality rate for persons with non-PCV7 serotype IPD
U2 - https://doi.org/10.3201/eid1811.120329
DO - https://doi.org/10.3201/eid1811.120329
M3 - Article
C2 - 23092683
SN - 1080-6040
VL - 18
SP - 1729
EP - 1737
JO - Emerging infectious diseases
JF - Emerging infectious diseases
IS - 11
ER -