TY - JOUR
T1 - Investigating Serotonergic Function Using Positron Emission Tomography: Overview and Recent Findings
AU - Veltman, D.J.
AU - Ruhe, H.G.
AU - Booij, J.
PY - 2010
Y1 - 2010
N2 - Mono-aminergic neurotransmitters, in particular serotonin (5-HT), are involved in regulating a large number of psychological and physiological functions, and abnormal 5-HT transmission has been implicated in a wide variety of neuropsychiatric disorders. Positron emission tomography (PET) is a non-invasive nuclear imaging technique with exquisite sensitivity and specificity, allowing delineation of neurotransmitter function in vivo. Over the last two decades, PET has been used to investigate 5-HT function in several neuropsychiatric disorders, in particular mood and anxiety disorders, schizophrenia, Alzheimer's disease, and impulse control disorders. In the present review, an overview of recent findings is provided, and possibilities for further research are discussed
AB - Mono-aminergic neurotransmitters, in particular serotonin (5-HT), are involved in regulating a large number of psychological and physiological functions, and abnormal 5-HT transmission has been implicated in a wide variety of neuropsychiatric disorders. Positron emission tomography (PET) is a non-invasive nuclear imaging technique with exquisite sensitivity and specificity, allowing delineation of neurotransmitter function in vivo. Over the last two decades, PET has been used to investigate 5-HT function in several neuropsychiatric disorders, in particular mood and anxiety disorders, schizophrenia, Alzheimer's disease, and impulse control disorders. In the present review, an overview of recent findings is provided, and possibilities for further research are discussed
U2 - https://doi.org/10.2174/138161210791293033
DO - https://doi.org/10.2174/138161210791293033
M3 - Article
C2 - 20370665
SN - 1381-6128
VL - 16
SP - 1979
EP - 1989
JO - Current pharmaceutical design
JF - Current pharmaceutical design
IS - 18
ER -