Is joint hypermobility associated with vesico-ureteral reflux? An assessment of 50 patients

Albertien M. van Eerde; Virginie J.M. Verhoeven; Tom P.V.M. de Jong; Elise M. van de Putte; Jacques C. Giltay; Raoul H.H. Engelbert

doi:https://doi.org/10.1111/j.1464-410X.2011.10469.x

Is joint hypermobility associated with vesico-ureteral reflux? An assessment of 50 patients

Albertien M. van Eerde, Virginie J.M. Verhoeven, Tom P.V.M. de Jong, Elise M. van de Putte, Jacques C. Giltay, Raoul H.H. Engelbert

Research output: Contribution to journal › Article › Academic › peer-review

10 Citations (Scopus)

Abstract

Study Type – Aetiology (individual cohort)

Level of Evidence 2b

What's known on the subject? and What does the study add?

Recent studies have already shown associations between generalized joint hypermobility (GJH) and voiding and defecation dysfunction and/or slow transit constipation. Changes in extracellular matrix composition in vesico‐ureteric junction of vesico‐ureteral reflux (VUR) patients were also observed previously.

This study is the first to assess joint mobility as a parameter for connective tissue composition in vesico‐ureteral reflux. We convincingly demonstrate that VUR patients have significantly more hypermobile joints compared to controls and this provides a new angle to the intriguing subjects of development of VUR and susceptibility to VUR.

OBJECTIVE

•

To assess whether there is an increased prevalence of joint hypermobility in patients with vesico‐ureteric reflux (VUR).

MATERIALS AND METHODS

•

We studied 50 patients with primary VUR and matched controls drawn from a reference population.

•

Joint mobility was assessed using the Bulbena hypermobility score.

RESULTS

•

We identified significantly more patients with VUR with generalized joint hypermobility than controls (24% vs 6.7%, P= 0.007).

CONCLUSION

•

Our findings confirm our clinical observation of an increased rate of joint hypermobility in patients with VUR. We speculate that an altered composition of the connective tissue may contribute to the severity of the (pre‐existing) VUR phenotype.

Original language	English
Pages (from-to)	1243-1248
Journal	BJU international
Volume	109
Issue number	8
DOIs	https://doi.org/10.1111/j.1464-410X.2011.10469.x
Publication status	Published - Apr 2012

Keywords

connective tissue
extracellular matrix
joint instability
urinary tract infections
vesico-ureteric reflux

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https://doi.org/10.1111/j.1464-410X.2011.10469.x

https://pure.hva.nl/ws/files/6839793/j.1464_410X.2011.10469.x.pdf

Cite this

@article{cfb9b81eeae34a25af9521ffb011fb27,

title = "Is joint hypermobility associated with vesico-ureteral reflux? An assessment of 50 patients",

abstract = "Study Type – Aetiology (individual cohort)Level of Evidence 2bWhat's known on the subject? and What does the study add?Recent studies have already shown associations between generalized joint hypermobility (GJH) and voiding and defecation dysfunction and/or slow transit constipation. Changes in extracellular matrix composition in vesico‐ureteric junction of vesico‐ureteral reflux (VUR) patients were also observed previously.This study is the first to assess joint mobility as a parameter for connective tissue composition in vesico‐ureteral reflux. We convincingly demonstrate that VUR patients have significantly more hypermobile joints compared to controls and this provides a new angle to the intriguing subjects of development of VUR and susceptibility to VUR.OBJECTIVE•To assess whether there is an increased prevalence of joint hypermobility in patients with vesico‐ureteric reflux (VUR).MATERIALS AND METHODS•We studied 50 patients with primary VUR and matched controls drawn from a reference population.•Joint mobility was assessed using the Bulbena hypermobility score.RESULTS•We identified significantly more patients with VUR with generalized joint hypermobility than controls (24% vs 6.7%, P= 0.007).CONCLUSION•Our findings confirm our clinical observation of an increased rate of joint hypermobility in patients with VUR. We speculate that an altered composition of the connective tissue may contribute to the severity of the (pre‐existing) VUR phenotype.",

keywords = "connective tissue, extracellular matrix, joint instability, urinary tract infections, vesico-ureteric reflux",

author = "{van Eerde}, {Albertien M.} and Verhoeven, {Virginie J.M.} and {de Jong}, {Tom P.V.M.} and {van de Putte}, {Elise M.} and Giltay, {Jacques C.} and Engelbert, {Raoul H.H.}",

note = "Journal: Online ISSN:1464-410X.",

year = "2012",

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doi = "https://doi.org/10.1111/j.1464-410X.2011.10469.x",

language = "English",

volume = "109",

pages = "1243--1248",

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TY - JOUR

T1 - Is joint hypermobility associated with vesico-ureteral reflux? An assessment of 50 patients

AU - van Eerde, Albertien M.

AU - Verhoeven, Virginie J.M.

AU - de Jong, Tom P.V.M.

AU - van de Putte, Elise M.

AU - Giltay, Jacques C.

AU - Engelbert, Raoul H.H.

N1 - Journal: Online ISSN:1464-410X.

PY - 2012/4

Y1 - 2012/4

N2 - Study Type – Aetiology (individual cohort)Level of Evidence 2bWhat's known on the subject? and What does the study add?Recent studies have already shown associations between generalized joint hypermobility (GJH) and voiding and defecation dysfunction and/or slow transit constipation. Changes in extracellular matrix composition in vesico‐ureteric junction of vesico‐ureteral reflux (VUR) patients were also observed previously.This study is the first to assess joint mobility as a parameter for connective tissue composition in vesico‐ureteral reflux. We convincingly demonstrate that VUR patients have significantly more hypermobile joints compared to controls and this provides a new angle to the intriguing subjects of development of VUR and susceptibility to VUR.OBJECTIVE•To assess whether there is an increased prevalence of joint hypermobility in patients with vesico‐ureteric reflux (VUR).MATERIALS AND METHODS•We studied 50 patients with primary VUR and matched controls drawn from a reference population.•Joint mobility was assessed using the Bulbena hypermobility score.RESULTS•We identified significantly more patients with VUR with generalized joint hypermobility than controls (24% vs 6.7%, P= 0.007).CONCLUSION•Our findings confirm our clinical observation of an increased rate of joint hypermobility in patients with VUR. We speculate that an altered composition of the connective tissue may contribute to the severity of the (pre‐existing) VUR phenotype.

AB - Study Type – Aetiology (individual cohort)Level of Evidence 2bWhat's known on the subject? and What does the study add?Recent studies have already shown associations between generalized joint hypermobility (GJH) and voiding and defecation dysfunction and/or slow transit constipation. Changes in extracellular matrix composition in vesico‐ureteric junction of vesico‐ureteral reflux (VUR) patients were also observed previously.This study is the first to assess joint mobility as a parameter for connective tissue composition in vesico‐ureteral reflux. We convincingly demonstrate that VUR patients have significantly more hypermobile joints compared to controls and this provides a new angle to the intriguing subjects of development of VUR and susceptibility to VUR.OBJECTIVE•To assess whether there is an increased prevalence of joint hypermobility in patients with vesico‐ureteric reflux (VUR).MATERIALS AND METHODS•We studied 50 patients with primary VUR and matched controls drawn from a reference population.•Joint mobility was assessed using the Bulbena hypermobility score.RESULTS•We identified significantly more patients with VUR with generalized joint hypermobility than controls (24% vs 6.7%, P= 0.007).CONCLUSION•Our findings confirm our clinical observation of an increased rate of joint hypermobility in patients with VUR. We speculate that an altered composition of the connective tissue may contribute to the severity of the (pre‐existing) VUR phenotype.

KW - connective tissue

KW - extracellular matrix

KW - joint instability

KW - urinary tract infections

KW - vesico-ureteric reflux

U2 - https://doi.org/10.1111/j.1464-410X.2011.10469.x

DO - https://doi.org/10.1111/j.1464-410X.2011.10469.x

M3 - Article

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SN - 1464-4096

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SP - 1243

EP - 1248

JO - BJU international

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