Isolated lung perfusion for pulmonary metastases, a review and work in progress

Marco J. J. H. Grootenboers, Jos Heeren, Bart P. van Putte, Jeroen M. H. Hendriks, Wim J. van Boven, Paul E. Y. van Schil, Franz M. N. H. Schramel

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13 Citations (Scopus)


Pulmonary metastasectomy is a widely accepted treatment for many patients with pulmonary metastases from various solid tumors. Nevertheless, 5-year survival is disappointing, with rates of 25-40%, and many patients develop recurrences. Isolated lung perfusion (ILuP) is a promising new technique to deliver high-dose chemotherapy to the lungs, while minimising systemic toxicities. This procedure is technically safe and feasible; however, clinical value and efficacy remain unclear. The aim of this paper is to give a review of literature on ILuP in humans, and to describe the development of the perfusion procedure in our institute
Original languageEnglish
Pages (from-to)267-276
Issue number5
Publication statusPublished - 2006
Externally publishedYes

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