Klotho and aging phenotypes

Marc G. Vervloet, Jan-Luuk Hillebrands

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

1 Citation (Scopus)


It is well established that animal models of α-Klotho deficiency are characterized by an aging phenotype. With the advent of research in the biological mechanisms of aging it has become clear that the kidney-derived α-Klotho protein has a key role in these mechanisms, generally retarding the aging process. In this chapter, the fundamental aspects of aging are discussed with a focus on the integrated role of α-Klotho. In addition, the striking similarities of key aspects of aging and α-Klotho deficiency on the level of several organ systems and tissues are described in detail. In particular, the effects on the cardiovascular system, the lungs, bone, and the central nervous system are addressed. Collectively, it is demonstrated that the role of α-Klotho in these processes is of paramount importance and that modulating its abundance may be a tool to target the aging process and associated morbidity that develops as a consequence of disease-induced α-Klotho suppression in the nearby future.
Original languageEnglish
Title of host publicationFibroblast Growth Factor 23
ISBN (Electronic)9780128180365
Publication statusPublished - 1 Jan 2021

Publication series

NameFibroblast Growth Factor 23

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