Laag geboortegewicht: Consequenties voor de nier?

Translated title of the contribution: Does a low birth weight have consequences for the kidney?

M. F. Schreuder, M. Fodor, J. A.E. Van Wijk, H. A. Delemarre-Van De Waal

Research output: Contribution to journalReview articleAcademicpeer-review

1 Citation (Scopus)


In recent years, a relation has been shown between low birth weight and a higher risk of diseases in adult life, particularly hypertension, cardiovascular diseases and type 2 diabetes. Causal factor could be intrauterine growth retardation, which interferes with the development and function of organs (called programming). Human and animal studies show that programming of the kidney leads to a reduced number of nephrons. In order to compensate, there is hyperfiltration in remnant nephrons, leading to glomerular and systemic hypertension and glomerulosclerosis, with renal failure as endpoint. Oligonephronia makes the kidneys more vulnerable: in case of accessory renal disease, prognosis seems to deteriorate with low birth weight. The renin-angiotensin system (RAS) appears to play an important role based on its influence on renal hemodynamics, which is altered when associated with low birth weight. Animal studies suggest the RAS as means for pharmacological manipulation of the low birth weight consequences. However, more data is needed before coming to clinical implications.

Translated title of the contributionDoes a low birth weight have consequences for the kidney?
Original languageDutch
Pages (from-to)178-182
Number of pages5
JournalTijdschrift voor kindergeneeskunde
Issue number5
Publication statusPublished - Oct 2002

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