TY - JOUR
T1 - Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection
AU - COVID Human Genetic Effort
AU - COVIDeF Study Group
AU - French COVID Cohort Study Group
AU - CoV-Contact Cohort
AU - COVID-STORM Clinicians
AU - COVID Clinicians
AU - Orchestra Working Group
AU - Amsterdam UMC Covid-19 Biobank
AU - NIAID-USUHS COVID Study Group
AU - Marchal, Astrid
AU - Cirulli, Elizabeth T.
AU - Neveux, Iva
AU - Bellos, Evangelos
AU - Thwaites, Ryan S.
AU - Schiabor Barrett, Kelly M.
AU - Zhang, Yu
AU - Nemes-Bokun, Ivana
AU - Kalinova, Mariya
AU - Catchpole, Andrew
AU - Tangye, Stuart G.
AU - Spaan, András N.
AU - Lack, Justin B.
AU - Ghosn, Jade
AU - Burdet, Charles
AU - Gorochov, Guy
AU - Tubach, Florence
AU - Hausfater, Pierre
AU - Abel, Laurent
AU - Aiuti, Alessandro
AU - Al-Muhsen, Saleh
AU - Al-Mulla, Fahd
AU - Amara, Ali
AU - Anderson, Mark S.
AU - Andreakos, Evangelos
AU - Arias, Andrés A.
AU - Arkin, Lisa M.
AU - van Agtmael, Michiel
AU - Beudel, Martijn
AU - Bogaard, Harm Jan
AU - Bomers, Marije
AU - Bonta, Peter
AU - Bos, Lieuwe
AU - de Brabander, Justin
AU - Bugiani, Marianna
AU - Elbers, Paul
AU - Fleuren, Lucas
AU - Geerlings, Suzanne
AU - Hemke, Robert
AU - Hermans, Sabine M.
AU - de Jong, Menno D.
AU - Lim, Endry H.T.
AU - Nossent, Esther J.
AU - Peters, Edgar
AU - Prins, Jan M.
AU - Sigaloff, Kim
AU - Teunissen, Charlotte
AU - Thoral, Patrick
AU - Tuinman, Pieter R.
AU - de Vries, Heder
N1 - Publisher Copyright: © 2024 The Author(s)
PY - 2024/7/18
Y1 - 2024/7/18
N2 - Human genetic studies of critical COVID-19 pneumonia have revealed the essential role of type I interferon-dependent innate immunity to SARS-CoV-2 infection. Conversely, an association between the HLA-B∗15:01 allele and asymptomatic SARS-CoV-2 infection in unvaccinated individuals was recently reported, suggesting a contribution of pre-existing T cell-dependent adaptive immunity. We report a lack of association of classical HLA alleles, including HLA-B∗15:01, with pre-omicron asymptomatic SARS-CoV-2 infection in unvaccinated participants in a prospective population-based study in the United States (191 asymptomatic vs. 945 symptomatic COVID-19 cases). Moreover, we found no such association in the international COVID Human Genetic Effort cohort (206 asymptomatic vs. 574 mild or moderate COVID-19 cases and 1,625 severe or critical COVID-19 cases). Finally, in the Human Challenge Characterisation study, the three HLA-B∗15:01 individuals infected with SARS-CoV-2 developed symptoms. As with other acute primary infections studied, no classical HLA alleles favoring an asymptomatic course of SARS-CoV-2 infection were identified.
AB - Human genetic studies of critical COVID-19 pneumonia have revealed the essential role of type I interferon-dependent innate immunity to SARS-CoV-2 infection. Conversely, an association between the HLA-B∗15:01 allele and asymptomatic SARS-CoV-2 infection in unvaccinated individuals was recently reported, suggesting a contribution of pre-existing T cell-dependent adaptive immunity. We report a lack of association of classical HLA alleles, including HLA-B∗15:01, with pre-omicron asymptomatic SARS-CoV-2 infection in unvaccinated participants in a prospective population-based study in the United States (191 asymptomatic vs. 945 symptomatic COVID-19 cases). Moreover, we found no such association in the international COVID Human Genetic Effort cohort (206 asymptomatic vs. 574 mild or moderate COVID-19 cases and 1,625 severe or critical COVID-19 cases). Finally, in the Human Challenge Characterisation study, the three HLA-B∗15:01 individuals infected with SARS-CoV-2 developed symptoms. As with other acute primary infections studied, no classical HLA alleles favoring an asymptomatic course of SARS-CoV-2 infection were identified.
KW - association
KW - asymptomatic infection
KW - COVID-19
KW - HLA
KW - population stratification
UR - http://www.scopus.com/inward/record.url?scp=85195515679&partnerID=8YFLogxK
U2 - 10.1016/j.xhgg.2024.100300
DO - 10.1016/j.xhgg.2024.100300
M3 - Article
C2 - 38678364
SN - 2666-2477
VL - 5
JO - Human Genetics and Genomics Advances
JF - Human Genetics and Genomics Advances
IS - 3
M1 - 100300
ER -