Lack of effect of lithium on the renal response to DA1‐dopamine receptor stimulation by fenoldopam in normal man [see comments]

AR Girbes, AJ Smit, S. Meijer, WD Reitsma

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1. The effect of oral lithium (300 mg) on the renal response to the selective DA1‐dopamine receptor agonist fenoldopam was investigated in seven normal men. Lithium had no influence on sodium excretion and renal haemodynamics during fenoldopam infusion. The fenoldopam‐induced rise in PRA was enhanced in the presence of lithium. We conclude that a previously described interaction between lithium and the dopamine agonist gludopa is not mediated by DA1‐dopamine receptors or is confined to higher doses of lithium. 1990 The British Pharmacological Society

Original languageEnglish
Pages (from-to)413-415
Number of pages3
JournalBritish journal of clinical pharmacology
Issue number4
Publication statusPublished - 1 Jan 1990

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