Aim of the study was to assess the role of combination treat ment in bladder cancer patients presenting with supra-regional lymph node metastases only and a clinical complete or partial response after chemotherapy. We identified 14 patients with supra regional lymph node metastases out of 394 patients with transitional cell carcinoma (TCC) treated in our institute with cystectomy and regional and supra-regional lymph node dissection between 1987-2007. Prior to cystecto my chemotherapy had been given. 11 patients died due to bladder cancer, seven of them within one year after cystectomy. The 3- and 5-year disease-specific survival rates were 36% (95% C.I.:io%-6o% and 24% (95% C.I.: o%-49%). Mean follow-up was 2,5 years. Combination therapy consisting of chemotherapy and surgery in selected patients with tumor positive supra regional lymph nodes only can result in durable long term survival rates (24% 5-year survival). Response evaluation after chemotherapy may play a decisive role in the selection of patients undergoing subsequent surgical removal of all known tumor sites.
|Translated title of the contribution||Long-term survival after combined modality treatment in metastatic bladder cancer patients presenting with supra-regional tumor positive lymph nodes only|
|Number of pages||3|
|Journal||Nederlands Tijdschrift voor Urologie|
|Publication status||Published - May 2009|
- Bladder cancer, combination treatment
- Lymph node metastases