TY - JOUR
T1 - Langerhans cells and viral immunity
AU - Cunningham, Anthony L.
AU - Carbone, Francis
AU - Geijtenbeek, Teunis B. H.
PY - 2008
Y1 - 2008
N2 - Langerhans cells (LC) are a unique dendritic cell subset that are located in mucosal stratified squamous epithelium and skin epidermis. Their location is ideally suited for their function as antigen presenting cells that capture invading viruses and induce anti-viral immunity. However, it is becoming evident that the interaction between LC and viruses can result in different responses, depending on the virus and the receptors involved. Here we will discuss the recent data on the similarities and differences in roles of LC in viral immunity to and infection with HIV, herpes simplex and varicella-zoster virus. Although all three viruses interact with LC during initial infection, the effects can be quite different, reflecting differences in biology and pathogenesis
AB - Langerhans cells (LC) are a unique dendritic cell subset that are located in mucosal stratified squamous epithelium and skin epidermis. Their location is ideally suited for their function as antigen presenting cells that capture invading viruses and induce anti-viral immunity. However, it is becoming evident that the interaction between LC and viruses can result in different responses, depending on the virus and the receptors involved. Here we will discuss the recent data on the similarities and differences in roles of LC in viral immunity to and infection with HIV, herpes simplex and varicella-zoster virus. Although all three viruses interact with LC during initial infection, the effects can be quite different, reflecting differences in biology and pathogenesis
U2 - https://doi.org/10.1002/eji.200838521
DO - https://doi.org/10.1002/eji.200838521
M3 - Review article
C2 - 18792031
SN - 0014-2980
VL - 38
SP - 2377
EP - 2385
JO - European journal of immunology
JF - European journal of immunology
IS - 9
ER -