Langerhans cells and viral immunity

Anthony L. Cunningham, Francis Carbone, Teunis B. H. Geijtenbeek

Research output: Contribution to journalReview articleAcademicpeer-review


Langerhans cells (LC) are a unique dendritic cell subset that are located in mucosal stratified squamous epithelium and skin epidermis. Their location is ideally suited for their function as antigen presenting cells that capture invading viruses and induce anti-viral immunity. However, it is becoming evident that the interaction between LC and viruses can result in different responses, depending on the virus and the receptors involved. Here we will discuss the recent data on the similarities and differences in roles of LC in viral immunity to and infection with HIV, herpes simplex and varicella-zoster virus. Although all three viruses interact with LC during initial infection, the effects can be quite different, reflecting differences in biology and pathogenesis
Original languageEnglish
Pages (from-to)2377-2385
JournalEuropean Journal of Immunology
Issue number9
Publication statusPublished - 2008

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