Large-scale classification of major depressive disorder via distributed Lasso

Dajiang Zhu, Qingyang Li, Brandalyn C. Riedel, Neda Jahanshad, Derrek P. Hibar, Ilya M. Veer, Henrik Walter, Lianne Schmaal, Dick J. Veltman, Dominik Grotegerd, Udo Dannlowski, Matthew D. Sacchet, Ian H. Gotlib, Jieping Ye, Paul M. Thompson

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

2 Citations (Scopus)

Abstract

Compared to many neurological disorders, for which imaging biomarkers are often available, there are no accepted imaging biomarkers to assist in the diagnosis of major depressive disorder (MDD). One major barrier to understanding MDD has been the lack of a practical and efficient platform for collaborative efforts across multiple data centers; integrating the knowledge from different centers should make it easier to identify characteristic measures that are consistently associated with the illness. Here we applied our newly developed "distributed Lasso" method to brain MRI data from multiple centers to perform feature selection and classification. Over 1,000 participants were involved in the study; our results indicate the potential of the proposed framework to enable large-scale collaborative data analysis in the future.

Original languageEnglish
Title of host publication12th International Symposium on Medical Information Processing and Analysis
EditorsEduardo Romero, Natasha Lepore, Jorge Brieva, Ignacio Larrabide
PublisherSPIE
ISBN (Electronic)9781510607781
DOIs
Publication statusPublished - 2017
Event12th International Symposium on Medical Information Processing and Analysis, SIPAIM 2016 - Tandil, Argentina
Duration: 5 Dec 20167 Dec 2016

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume10160

Conference

Conference12th International Symposium on Medical Information Processing and Analysis, SIPAIM 2016
Country/TerritoryArgentina
CityTandil
Period5/12/20167/12/2016

Keywords

  • Distributed Lasso
  • ENIGMA

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