Large-scale surveillance of Plasmodium falciparum crt(K76T) in northern Ghana

Stephan Ehrhardt, Teunis A. Eggelte, Sarah Kaiser, Lydia Adjei, Gerd D. Burchard, Sylvester D. Anemana, Ulrich Bienzle, Frank P. Mockenhaupt

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Surveillance of Plasmodium falciparum crt(K76T) [Pfcrt(K76T)], a resistance marker of chloroquine and, limitedly, amodiaquine, in >4,000 children in northern Ghana revealed a prevalence of 79%. Pfcrt(K76T) was heterogeneously distributed and associated with chloroquine use, low parasitemia, and the dry season. Widespread chloroquine resistance challenges the regional life span of amodiaquine as a partner drug in artemisinin combination therapy
Original languageEnglish
Pages (from-to)3407-3409
JournalAntimicrobial Agents and Chemotherapy
Issue number9
Publication statusPublished - 2007

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