Lasting synaptic changes underlie attention deficits caused by nicotine exposure during adolescence

D.S. Counotte; N.A. Goriounova; K.W. Li; M. Loos; R.C. van der Schors; D. Schetters; A.N.M. Schoffelmeer; A.B. Smit; H.D. Mansvelder; T. Pattij; S. Spijker

doi:https://doi.org/10.1038/nn.2770

Lasting synaptic changes underlie attention deficits caused by nicotine exposure during adolescence

D.S. Counotte, N.A. Goriounova, K.W. Li, M. Loos, R.C. van der Schors, D. Schetters, A.N.M. Schoffelmeer, A.B. Smit, H.D. Mansvelder, T. Pattij, S. Spijker

Anatomy and neurosciences (VUmc)

Research output: Contribution to journal › Article › Academic › peer-review

108 Citations (Scopus)

Abstract

Tobacco smoking and nicotine exposure during adolescence interfere with prefrontal cortex (PFC) development and lead to cognitive impairments in later life. The molecular and cellular underpinnings of these consequences remain elusive. We found that adolescent nicotine exposure induced lasting attentional disturbances and reduced mGluR2 protein and function on presynaptic terminals of PFC glutamatergic synapses. Restoring mGluR2 activity in vivo by local infusion of a group II mGluR agonist in adult rats that received nicotine as adolescents rescued attentional disturbances. © 2011 Nature America, Inc. All rights reserved.

Original language	English
Pages (from-to)	417-419
Number of pages	2
Journal	Nature neuroscience
Volume	14
Issue number	4
DOIs	https://doi.org/10.1038/nn.2770
Publication status	Published - 2011

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

https://doi.org/10.1038/nn.2770

Cite this

@article{dbaad3603bc1477b8208fc2a3fb6920a,

title = "Lasting synaptic changes underlie attention deficits caused by nicotine exposure during adolescence",

abstract = "Tobacco smoking and nicotine exposure during adolescence interfere with prefrontal cortex (PFC) development and lead to cognitive impairments in later life. The molecular and cellular underpinnings of these consequences remain elusive. We found that adolescent nicotine exposure induced lasting attentional disturbances and reduced mGluR2 protein and function on presynaptic terminals of PFC glutamatergic synapses. Restoring mGluR2 activity in vivo by local infusion of a group II mGluR agonist in adult rats that received nicotine as adolescents rescued attentional disturbances. {\textcopyright} 2011 Nature America, Inc. All rights reserved.",

author = "D.S. Counotte and N.A. Goriounova and K.W. Li and M. Loos and {van der Schors}, R.C. and D. Schetters and A.N.M. Schoffelmeer and A.B. Smit and H.D. Mansvelder and T. Pattij and S. Spijker",

year = "2011",

doi = "https://doi.org/10.1038/nn.2770",

language = "English",

volume = "14",

pages = "417--419",

journal = "Nature neuroscience",

issn = "1097-6256",

publisher = "Nature Publishing Group",

number = "4",

}

TY - JOUR

T1 - Lasting synaptic changes underlie attention deficits caused by nicotine exposure during adolescence

AU - Counotte, D.S.

AU - Goriounova, N.A.

AU - Li, K.W.

AU - Loos, M.

AU - van der Schors, R.C.

AU - Schetters, D.

AU - Schoffelmeer, A.N.M.

AU - Smit, A.B.

AU - Mansvelder, H.D.

AU - Pattij, T.

AU - Spijker, S.

PY - 2011

Y1 - 2011

N2 - Tobacco smoking and nicotine exposure during adolescence interfere with prefrontal cortex (PFC) development and lead to cognitive impairments in later life. The molecular and cellular underpinnings of these consequences remain elusive. We found that adolescent nicotine exposure induced lasting attentional disturbances and reduced mGluR2 protein and function on presynaptic terminals of PFC glutamatergic synapses. Restoring mGluR2 activity in vivo by local infusion of a group II mGluR agonist in adult rats that received nicotine as adolescents rescued attentional disturbances. © 2011 Nature America, Inc. All rights reserved.

AB - Tobacco smoking and nicotine exposure during adolescence interfere with prefrontal cortex (PFC) development and lead to cognitive impairments in later life. The molecular and cellular underpinnings of these consequences remain elusive. We found that adolescent nicotine exposure induced lasting attentional disturbances and reduced mGluR2 protein and function on presynaptic terminals of PFC glutamatergic synapses. Restoring mGluR2 activity in vivo by local infusion of a group II mGluR agonist in adult rats that received nicotine as adolescents rescued attentional disturbances. © 2011 Nature America, Inc. All rights reserved.

U2 - https://doi.org/10.1038/nn.2770

DO - https://doi.org/10.1038/nn.2770

M3 - Article

C2 - 21336271

SN - 1097-6256

VL - 14

SP - 417

EP - 419

JO - Nature neuroscience

JF - Nature neuroscience

IS - 4

ER -