TY - JOUR
T1 - Late Mortality in Childhood Cancer Survivors according to Pediatric Cancer Diagnosis and Treatment Era in the Dutch LATER Cohort
AU - Kilsdonk, Ellen
AU - van Dulmen-den Broeder, Eline
AU - van Leeuwen, Flora E.
AU - van den Heuvel-Eibrink, Marry M.
AU - Loonen, Jacqueline J.
AU - van der Pal, Helena J.
AU - Bresters, Dorine
AU - Versluys, A. B.
AU - Pieters, Rob
AU - Hauptmann, Michael
AU - Jaspers, Monique W. M.
AU - Neggers, Sebastian J. C.
AU - Raphael, Martine F.
AU - LATER Study Group
AU - Tissing, Wim J. E.
AU - Kremer, Leontine C. M.
AU - Ronckers, C. cile M.
N1 - Funding Information: This study was financially supported by the European Union’s Seventh Framework Programme for Research, Technological Development and Demonstration [Grant Agreement No. 257505; PanCareSurFup] and by Dutch Cancer Society [DCS grants DCOG.2011-5027 and UvA.2012-5517]. This work was also supported by KWF. We thank Ms. Ingeborg Lange, Ms. Bep Verkerk, and Mr. Dennis de Jongh for data-management and ICT support in various stages of this work, the local study data-managers in each of the seven -LATER centers and the DCOG trial bureau staff (Head J Lieverst) for their help in data collection. Furthermore, we thank the following (former) members of the LATER Study Group for their contributions: Lilian Batenburg, Huib Caron, Wil Dolsma, Gea Huizinga, Marloes Louwerens, Hanneke de Ridder, Lideke van der Steeg, Margreet Veening, and Andrica de Vries. Publisher Copyright: © 2022 The Author(s). Published with license by Taylor and Francis Group, LLC.
PY - 2022/5/1
Y1 - 2022/5/1
N2 - This multi-center cohort-study examined late mortality among 6,165 Dutch five-year childhood cancer survivors diagnosed 1963-2001. Clinical details and cause of death were based on medical records. Mortality was 12-fold that of the general population, with 51.3 additional deaths per 10,000 person-years (21.9 yrs median follow-up). Cumulative mortality 15 yrs post-diagnosis was 6.9%, predominantly from late recurrences; thereafter the absolute contribution of other health outcomes increased. Cumulative all-cause and recurrence-related mortality were highest for Central Nervous System and bone tumor survivors. All-cause, but not subsequent tumor and circulatory disease-related cumulative mortality, was highest for patients diagnosed 1963-1979 vs. later (p-trend <0.001).
AB - This multi-center cohort-study examined late mortality among 6,165 Dutch five-year childhood cancer survivors diagnosed 1963-2001. Clinical details and cause of death were based on medical records. Mortality was 12-fold that of the general population, with 51.3 additional deaths per 10,000 person-years (21.9 yrs median follow-up). Cumulative mortality 15 yrs post-diagnosis was 6.9%, predominantly from late recurrences; thereafter the absolute contribution of other health outcomes increased. Cumulative all-cause and recurrence-related mortality were highest for Central Nervous System and bone tumor survivors. All-cause, but not subsequent tumor and circulatory disease-related cumulative mortality, was highest for patients diagnosed 1963-1979 vs. later (p-trend <0.001).
KW - Childhood cancer survivors
KW - late mortality
UR - http://www.scopus.com/inward/record.url?scp=85128800562&partnerID=8YFLogxK
U2 - https://doi.org/10.1080/07357907.2022.2034841
DO - https://doi.org/10.1080/07357907.2022.2034841
M3 - Article
C2 - 35175864
SN - 0735-7907
VL - 40
SP - 413
EP - 424
JO - Cancer Investigation
JF - Cancer Investigation
IS - 5
ER -