L'axe hormone de croissance/insulin-like growth factor. Quel rôle dans le processus athéroscléreux?

T. B. Twickler, E. Bruckert, M. J. M. Cramer, D. W. Erkelens, H. P. F. Koppeschaar

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

GROWTH HORMONE AND ATHEROSCLEROSIS: Adult-onset growth hormone (GH) deficiency is associated with an increase in cardiovascular morbidity and mortality. MECHANISMS: Other than classical risk factors, such as dyslipidemia, a direct interaction between the activity of the GH/IGF-1 axis and the endothelium also plays a part. It is possible that the modulating effect of IGF-1 on nitric oxide (NO) synthesis is also important, together with the anabolic effect on the myocardiocytes. Substitution of recombinant GH induces rapid reduction in the atherosclerotic plaques, suggesting a direct effect of the GH/IGF axis on the atherosclerotic process. In addition to the acquired GH deficiency, as in non-substituted patients following hypophysectomy, attention has recently been focused on the relative GH deficiency as is seen in obesity and in the course of ageing. PERSPECTIVES FOR CARDIOVASCULAR ENDOCRINOLOGY: Therapeutic intervention in the GH/IGF axis might influence the atherosclerotic process. Study of the GH/IGF axis activity and of its correlation with atherosclerosis opens new perspectives in the understanding of the role of this axis in cardiovascular diseases
Original languageEnglish
Pages (from-to)1238-1243
JournalPresse medicale (Paris, France
Volume32
Issue number26
Publication statusPublished - 2003

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