TY - JOUR
T1 - LDL-cholesterol and platelets: Insights into their interactions in atherosclerosis
AU - Gąsecka, Aleksandra
AU - Rogula, Sylwester
AU - Szarpak, Łukasz
AU - Filipiak, Krzysztof J.
N1 - Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/1/1
Y1 - 2021/1/1
N2 - Atherosclerosis and its complications, including acute coronary syndromes, are the major cause of death worldwide. The two most important pathophysiological mechanisms underlying atherosclerosis include increased platelet activation and increased low-density lipoproteins (LDL) concentration. In contrast to LDL, oxidized (ox)-LDL have direct pro-thrombotic properties by functional interactions with platelets, leading to platelet activation and favoring thrombus formation. In this review, we summarize the currently available evidence on the interactions between LDL-cholesterol and platelets, which are based on (i) the presence of ox-LDL-binding sites on platelets, (ii) generation of ox-LDL by platelets and (iii) the role of activated platelets and ox-LDL in atherosclerosis. In addition, we elaborate on the clinical implications of these interactions, including development of the new therapeutic possibilities. The ability to understand and modulate mechanisms governing interactions between LDL-cholesterol and platelets may offer new treatment strategies for atherosclerosis prevention.
AB - Atherosclerosis and its complications, including acute coronary syndromes, are the major cause of death worldwide. The two most important pathophysiological mechanisms underlying atherosclerosis include increased platelet activation and increased low-density lipoproteins (LDL) concentration. In contrast to LDL, oxidized (ox)-LDL have direct pro-thrombotic properties by functional interactions with platelets, leading to platelet activation and favoring thrombus formation. In this review, we summarize the currently available evidence on the interactions between LDL-cholesterol and platelets, which are based on (i) the presence of ox-LDL-binding sites on platelets, (ii) generation of ox-LDL by platelets and (iii) the role of activated platelets and ox-LDL in atherosclerosis. In addition, we elaborate on the clinical implications of these interactions, including development of the new therapeutic possibilities. The ability to understand and modulate mechanisms governing interactions between LDL-cholesterol and platelets may offer new treatment strategies for atherosclerosis prevention.
KW - Atherosclerosis
KW - Extracellular vesicles
KW - LDL-cholesterol
KW - Platelets
KW - Treatment
UR - http://www.scopus.com/inward/record.url?scp=85099438449&partnerID=8YFLogxK
U2 - https://doi.org/10.3390/life11010039
DO - https://doi.org/10.3390/life11010039
M3 - Review article
C2 - 33440673
SN - 2075-1729
VL - 11
SP - 1
EP - 13
JO - Life (Basel, Switzerland)
JF - Life (Basel, Switzerland)
IS - 1
M1 - 39
ER -