@inproceedings{2db4a2f9dcc34746a5e1371db42d056c,
title = "Learning Interpretable Regularized Ordinal Models from 3D Mesh Data for Neurodegenerative Disease Staging",
abstract = "We extend the sparse, spatially piecewise-contiguous linear classification framework for mesh-based data to ordinal logistic regression. The algorithm is intended for use with subcortical shape and cortical thickness data where progressive clinical staging is available, as is generally the case in neurodegenerative diseases. We apply the tool to Parkinson{\textquoteright}s and Alzheimer{\textquoteright}s disease staging. The resulting biomarkers predict Hoehn-Yahr and cognitive impairment stages at competitive accuracy; the models remain parsimonious and outperform one-against-all models in terms of the Akaike and Bayesian information criteria.",
keywords = "Imaging biomarker, Neurodegenerative Disease, Ordinal regression",
author = "Yuji Zhao and Laansma, {Max A.} and {van Heese}, {Eva M.} and Conor Owens-Walton and Parkes, {Laura M.} and Ines Debove and Christian Rummel and Roland Wiest and Fernando Cendes and Rachel Guimaraes and Yasuda, {Clarissa Lin} and Jiun-Jie Wang and Anderson, {Tim J.} and Dalrymple-Alford, {John C.} and Melzer, {Tracy R.} and Pitcher, {Toni L.} and Reinhold Schmidt and Petra Schwingenschuh and Garraux, {G. etan} and Mario Rango and Letizia Squarcina and Sarah Al-Bachari and Emsley, {Hedley C. A.} and Klein, {Johannes C.} and Mackay, {Clare E.} and Dirkx, {Michiel F.} and Rick Helmich and Francesca Assogna and Fabrizio Piras and Bright, {Joanna K.} and Gianfranco Spalletta and Kathleen Poston and Christine Lochner and McMillan, {Corey T.} and Daniel Weintraub and {ENIGMA Consortium} and Jason Druzgal and Benjamin Newman and {van den Heuvel}, {Odile A.} and Neda Jahanshad and Thompson, {Paul M.} and {van der Werf}, {Ysbrand D.} and Boris Gutman",
note = "Funding Information: Acknowledgments. Work by BG and YZ was supported by the Alzheimer{\textquoteright}s Association grant 2018-AARG-592081, Advanced Disconnectome Markers of Alzheimer{\textquoteright}s Disease. ENIGMA-PD (YW, PT, EH, ML) is supported by NINDS award 1RO1NS107513-01A. Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.; 5th International Workshop on Machine Learning in Clinical Neuroimaging, MLCN 2022, held in Conjunction with the 25th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2022 ; Conference date: 18-09-2022 Through 18-09-2022",
year = "2022",
doi = "https://doi.org/10.1007/978-3-031-17899-3_12",
language = "English",
isbn = "9783031178986",
volume = "13596 LNCS",
series = "Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",
publisher = "Springer Science and Business Media Deutschland GmbH",
pages = "115--124",
editor = "Ahmed Abdulkadir and Bathula, {Deepti R.} and Dvornek, {Nicha C.} and Mohamad Habes and Kia, {Seyed Mostafa} and Vinod Kumar and Thomas Wolfers",
booktitle = "Machine Learning in Clinical Neuroimaging - 5th International Workshop, MLCN 2022, Held in Conjunction with MICCAI 2022, Proceedings",
address = "Germany",
}