Length-dependent activation is modulated by cardiac troponin I bisphosphorylation at Ser23 and Ser24 but not by Thr143 phosphorylation

P.J.M. Wijnker; V. Sequeira Oliveira; D.B. Foster; Y.J. Li; C.G. dos Remedios; A.M. Murphy; G.J.M. Stienen; J. van der Velden

doi:https://doi.org/10.1152/ajpheart.00580.2013

Length-dependent activation is modulated by cardiac troponin I bisphosphorylation at Ser23 and Ser24 but not by Thr143 phosphorylation

P.J.M. Wijnker, V. Sequeira Oliveira, D.B. Foster, Y.J. Li, C.G. dos Remedios, A.M. Murphy, G.J.M. Stienen, J. van der Velden

Physiology (VUmc)

Research output: Contribution to journal › Article › Academic › peer-review

42 Citations (Scopus)

Abstract

Frank-Starling's law reflects the ability of the heart to adjust the force of its contraction to changes in ventricular filling, a property based on length-dependent myofilament activation (LDA). The threonine at amino acid 143 of cardiac troponin I (cTnI) is prerequisite for the length-dependent increase in Ca

Original language	English
Pages (from-to)	H1171-H1181
Journal	American journal of physiology. Heart and circulatory physiology
Volume	306
Issue number	8
DOIs	https://doi.org/10.1152/ajpheart.00580.2013
Publication status	Published - 2014

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Cite this

Wijnker, P. J. M., Sequeira Oliveira, V., Foster, D. B., Li, Y. J., dos Remedios, C. G., Murphy, A. M., Stienen, G. J. M., & van der Velden, J. (2014). Length-dependent activation is modulated by cardiac troponin I bisphosphorylation at Ser23 and Ser24 but not by Thr143 phosphorylation. American journal of physiology. Heart and circulatory physiology, 306(8), H1171-H1181. https://doi.org/10.1152/ajpheart.00580.2013

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abstract = "Frank-Starling's law reflects the ability of the heart to adjust the force of its contraction to changes in ventricular filling, a property based on length-dependent myofilament activation (LDA). The threonine at amino acid 143 of cardiac troponin I (cTnI) is prerequisite for the length-dependent increase in Ca",

author = "P.J.M. Wijnker and {Sequeira Oliveira}, V. and D.B. Foster and Y.J. Li and {dos Remedios}, C.G. and A.M. Murphy and G.J.M. Stienen and {van der Velden}, J.",

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Wijnker, PJM, Sequeira Oliveira, V, Foster, DB, Li, YJ, dos Remedios, CG, Murphy, AM, Stienen, GJM & van der Velden, J 2014, 'Length-dependent activation is modulated by cardiac troponin I bisphosphorylation at Ser23 and Ser24 but not by Thr143 phosphorylation', American journal of physiology. Heart and circulatory physiology, vol. 306, no. 8, pp. H1171-H1181. https://doi.org/10.1152/ajpheart.00580.2013

Length-dependent activation is modulated by cardiac troponin I bisphosphorylation at Ser23 and Ser24 but not by Thr143 phosphorylation. / Wijnker, P.J.M.; Sequeira Oliveira, V.; Foster, D.B. et al.
In: American journal of physiology. Heart and circulatory physiology, Vol. 306, No. 8, 2014, p. H1171-H1181.

Research output: Contribution to journal › Article › Academic › peer-review

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