Length-dependent activation is modulated by cardiac troponin I bisphosphorylation at Ser23 and Ser24 but not by Thr143 phosphorylation

P.J.M. Wijnker, V. Sequeira Oliveira, D.B. Foster, Y.J. Li, C.G. dos Remedios, A.M. Murphy, G.J.M. Stienen, J. van der Velden

Research output: Contribution to journalArticleAcademicpeer-review

41 Citations (Scopus)


Frank-Starling's law reflects the ability of the heart to adjust the force of its contraction to changes in ventricular filling, a property based on length-dependent myofilament activation (LDA). The threonine at amino acid 143 of cardiac troponin I (cTnI) is prerequisite for the length-dependent increase in Ca
Original languageEnglish
Pages (from-to)H1171-H1181
JournalAmerican journal of physiology. Heart and circulatory physiology
Issue number8
Publication statusPublished - 2014

Cite this