Lentivirus-mediated RNA interference of DC-SIGN expression inhibits human immunodeficiency virus transmission from dendritic cells to T cells.

JF Arrighi, M Pion, M Wiznerowicz, T.B.H. Geijtenbeek, E Garcia, S. Abraham, F Leuba, V Dutoit, O Ducrey-Rundquist, Y. van Kooijk, D Trono, V Piguet, M Wiznerowics, V Piquet, Jean-François Arrighi, Yvette van Kooyk

Research output: Contribution to journalArticleAcademicpeer-review

110 Citations (Scopus)


In the early events of human immunodeficiency virus type 1 (HIV-1) infection, immature dendritic cells (DCs) expressing the DC-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) receptor capture small amounts of HIV-1 on mucosal surfaces and spread viral infection to CD4
Original languageEnglish
Pages (from-to)10848-55
Number of pages8
JournalJournal of virology
Issue number20
Early online date1 Oct 2004
Publication statusPublished - Oct 2004


  • Amino Acid Sequence
  • Animals
  • Cell Adhesion Molecules/chemistry
  • Cell Line
  • Dendritic Cells/metabolism
  • Gene Silencing
  • HIV Envelope Protein gp120/metabolism
  • HIV Infections/transmission
  • HIV-1/pathogenicity
  • HeLa Cells
  • Humans
  • Lectins, C-Type/chemistry
  • Lentivirus/genetics
  • Macaca mulatta
  • Molecular Sequence Data
  • Pan troglodytes
  • RNA Interference
  • RNA, Messenger/genetics
  • RNA, Small Interfering/genetics
  • Receptors, Cell Surface/chemistry
  • T-Lymphocytes/virology

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