Liposomes bi-functionalized with phosphatidic acid and an ApoE-derived peptide affect A beta aggregation features and cross the blood-brain-barrier: Implications for therapy of Alzheimer disease

l. Bana, S. Minniti, S. Sesana, V. Zambelli, A. Cagnotto, A. Orlando, M. Cazzaniga, R. Zwart, W. Scheper, M. Masserini, F. Re, Elisa Salvati, Emanuela Cazzaniga

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Abstract

Targeting amyloid-β peptide (Aβ) within the brain is a strategy actively sought for therapy of Alzheimer's disease (AD). We investigated the ability of liposomes bi-functionalized with phosphatidic acid and with a modified ApoE-derived peptide (mApoE-PA-LIP) to affect Aβ aggregation/disaggregation features and to cross in vitro and in vivo the blood-brain barrier (BBB). Surface plasmon resonance showed that bi-functionalized liposomes strongly bind Aβ (k
Original languageEnglish
Pages (from-to)1583-1590
JournalNanomedicine: Nanotechnology, Biology and Medicine
Volume10
Issue number7
DOIs
Publication statusPublished - 2014

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