Abstract
Targeting amyloid-β peptide (Aβ) within the brain is a strategy actively sought for therapy of Alzheimer's disease (AD). We investigated the ability of liposomes bi-functionalized with phosphatidic acid and with a modified ApoE-derived peptide (mApoE-PA-LIP) to affect Aβ aggregation/disaggregation features and to cross in vitro and in vivo the blood-brain barrier (BBB). Surface plasmon resonance showed that bi-functionalized liposomes strongly bind Aβ (k
Original language | English |
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Pages (from-to) | 1583-1590 |
Journal | Nanomedicine: Nanotechnology, Biology and Medicine |
Volume | 10 |
Issue number | 7 |
DOIs | |
Publication status | Published - 2014 |