TY - JOUR
T1 - Local and systemic outcomes in DCIS based on tumor and patient characteristics: The radiation oncologist's perspective
AU - Bijker, Nina
AU - van tienhoven, Geertjan
PY - 2010
Y1 - 2010
N2 - Four randomized clinical trials have shown unanimously the benefit of 50 Gy whole-breast radiotherapy in breast-conserving therapy (BCT) for ductal carcinoma in situ (DCIS). The risk of both DCIS and invasive local recurrence is reduced with about 50%, and this effect is similar for all clinical and histological subgroups analyzed. Younger age and involved margin status are the most important factors for an increased risk of local recurrence. In these subgroups, even with radiotherapy, the observed local recurrence rates are more than 20% at 10 years, which is considerably higher than reported local recurrence rates after BCT for invasive breast cancer. The optimal radiotherapy dose in BCT for DCIS has yet to be established. Also, at present, a subgroup of lesions in which the recurrence rate is so low that radiotherapy can be safely omitted has not yet been identified. © The Author 2010. Published by Oxford University Press. All rights reserved.
AB - Four randomized clinical trials have shown unanimously the benefit of 50 Gy whole-breast radiotherapy in breast-conserving therapy (BCT) for ductal carcinoma in situ (DCIS). The risk of both DCIS and invasive local recurrence is reduced with about 50%, and this effect is similar for all clinical and histological subgroups analyzed. Younger age and involved margin status are the most important factors for an increased risk of local recurrence. In these subgroups, even with radiotherapy, the observed local recurrence rates are more than 20% at 10 years, which is considerably higher than reported local recurrence rates after BCT for invasive breast cancer. The optimal radiotherapy dose in BCT for DCIS has yet to be established. Also, at present, a subgroup of lesions in which the recurrence rate is so low that radiotherapy can be safely omitted has not yet been identified. © The Author 2010. Published by Oxford University Press. All rights reserved.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79952199008&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/20956825
U2 - https://doi.org/10.1093/jncimonographs/lgq025
DO - https://doi.org/10.1093/jncimonographs/lgq025
M3 - Article
C2 - 20956825
SN - 1052-6773
VL - 2010
SP - 178
EP - 180
JO - Journal of the National Cancer Institute - Monographs
JF - Journal of the National Cancer Institute - Monographs
IS - 41
ER -