TY - JOUR
T1 - Local staging with multiparametric MRI in daily clinical practice
T2 - diagnostic accuracy and evaluation of a radiologic learning curve
AU - Jansen, B. H. E.
AU - Oudshoorn, F. H. K.
AU - Tijans, A. M.
AU - Yska, M. J.
AU - Lont, A. P.
AU - Collette, E. R. P.
AU - Nieuwenhuijzen, J. A.
AU - Vis, A. N.
PY - 2018/9/1
Y1 - 2018/9/1
N2 - Purpose: To estimate the diagnostic accuracy of multiparametric MRI (mpMRI) for the detection of locally advanced prostate cancer (T-stage 3–4) prior to radical prostatectomy, in a multicenter cohort representing daily clinical practice. In addition, the radiologic learning curve for the detection of locally advanced disease is evaluated. Methods: Preoperative mpMRI findings of 430 patients (2012–2016) were compared to pathology results following radical prostatectomy. The diagnostic accuracy (sensitivity, specificity, PPV, and NPV) for the detection of locally advanced disease was calculated and compared for all years separately, to evaluate the presence of a radiological learning curve. Results: Of all 137 patients with locally advanced disease, 62 patients were preoperatively detected with mpMRI [sensitivity 45.3% (95% CI 36.9–53.6%), specificity 75.8% (CI 70.9–80.7%), PPV 46.6% (CI 38.1–55.1%), and NPV 74.7% (CI 69.8–79.7%)]. The diagnostic accuracy did not improve significantly over time (sensitivity p = 0.12; specificity p = 0.57). Conclusions: In daily clinical practice, the diagnostic accuracy of mpMRI for the detection of locally advanced prostate cancer remains limited. It, therefore, seems questionable whether mpMRI is adequate to guide preoperative decision-making. No significant radiologic learning curve for the detection of locally advance disease was observed.
AB - Purpose: To estimate the diagnostic accuracy of multiparametric MRI (mpMRI) for the detection of locally advanced prostate cancer (T-stage 3–4) prior to radical prostatectomy, in a multicenter cohort representing daily clinical practice. In addition, the radiologic learning curve for the detection of locally advanced disease is evaluated. Methods: Preoperative mpMRI findings of 430 patients (2012–2016) were compared to pathology results following radical prostatectomy. The diagnostic accuracy (sensitivity, specificity, PPV, and NPV) for the detection of locally advanced disease was calculated and compared for all years separately, to evaluate the presence of a radiological learning curve. Results: Of all 137 patients with locally advanced disease, 62 patients were preoperatively detected with mpMRI [sensitivity 45.3% (95% CI 36.9–53.6%), specificity 75.8% (CI 70.9–80.7%), PPV 46.6% (CI 38.1–55.1%), and NPV 74.7% (CI 69.8–79.7%)]. The diagnostic accuracy did not improve significantly over time (sensitivity p = 0.12; specificity p = 0.57). Conclusions: In daily clinical practice, the diagnostic accuracy of mpMRI for the detection of locally advanced prostate cancer remains limited. It, therefore, seems questionable whether mpMRI is adequate to guide preoperative decision-making. No significant radiologic learning curve for the detection of locally advance disease was observed.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85045754527&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/29680949
U2 - https://doi.org/10.1007/s00345-018-2295-6
DO - https://doi.org/10.1007/s00345-018-2295-6
M3 - Article
C2 - 29680949
SN - 0724-4983
VL - 36
SP - 1409
EP - 1415
JO - World Journal of Urology
JF - World Journal of Urology
IS - 9
ER -