LOCALIZED AND TEMPORAL GENE REGULATION IN HEART DEVELOPMENT

Phil Barnett; Malou van den Boogaard; Vincent Christoffels

doi:https://doi.org/10.1016/B978-0-12-387786-4.00004-X

LOCALIZED AND TEMPORAL GENE REGULATION IN HEART DEVELOPMENT

Phil Barnett, Malou van den Boogaard, Vincent Christoffels

Research output: Contribution to journal › Review article › Academic › peer-review

11 Citations (Scopus)

Abstract

The heart is a structurally complex and functionally heterogeneous organ. The repertoire of genes active in a given cardiac cell defines its shapes and function. This process of localized or heterogeneous gene expression is regulated to a large extent at the level of transcription, dictating the degree particular genes in a cell are active. Therefore, errors in the regulation of localized gene expression are at the basis of misregulation of the delicate process of heart development and function. In this review, we provide an overview of the origin of the different components of the vertebrate heart, and discuss our current understanding of the regulation of localized gene expression in the developing heart. We will also discuss where future research may lead to gain more insight into this process, which should provide much needed insight into the dysregulation of heart development and function, and the etiology of congenital defects

Original language	English
Pages (from-to)	171-201
Journal	Current topics in developmental biology
Volume	100
DOIs	https://doi.org/10.1016/B978-0-12-387786-4.00004-X
Publication status	Published - 2012

Access to Document

https://doi.org/10.1016/B978-0-12-387786-4.00004-X

Cite this

@article{7d231234920849348242381cdccfd1b5,

title = "LOCALIZED AND TEMPORAL GENE REGULATION IN HEART DEVELOPMENT",

abstract = "The heart is a structurally complex and functionally heterogeneous organ. The repertoire of genes active in a given cardiac cell defines its shapes and function. This process of localized or heterogeneous gene expression is regulated to a large extent at the level of transcription, dictating the degree particular genes in a cell are active. Therefore, errors in the regulation of localized gene expression are at the basis of misregulation of the delicate process of heart development and function. In this review, we provide an overview of the origin of the different components of the vertebrate heart, and discuss our current understanding of the regulation of localized gene expression in the developing heart. We will also discuss where future research may lead to gain more insight into this process, which should provide much needed insight into the dysregulation of heart development and function, and the etiology of congenital defects",

author = "Phil Barnett and {van den Boogaard}, Malou and Vincent Christoffels",

year = "2012",

doi = "https://doi.org/10.1016/B978-0-12-387786-4.00004-X",

language = "English",

volume = "100",

pages = "171--201",

journal = "Current topics in developmental biology",

issn = "0070-2153",

publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - LOCALIZED AND TEMPORAL GENE REGULATION IN HEART DEVELOPMENT

AU - Barnett, Phil

AU - van den Boogaard, Malou

AU - Christoffels, Vincent

PY - 2012

Y1 - 2012

N2 - The heart is a structurally complex and functionally heterogeneous organ. The repertoire of genes active in a given cardiac cell defines its shapes and function. This process of localized or heterogeneous gene expression is regulated to a large extent at the level of transcription, dictating the degree particular genes in a cell are active. Therefore, errors in the regulation of localized gene expression are at the basis of misregulation of the delicate process of heart development and function. In this review, we provide an overview of the origin of the different components of the vertebrate heart, and discuss our current understanding of the regulation of localized gene expression in the developing heart. We will also discuss where future research may lead to gain more insight into this process, which should provide much needed insight into the dysregulation of heart development and function, and the etiology of congenital defects

AB - The heart is a structurally complex and functionally heterogeneous organ. The repertoire of genes active in a given cardiac cell defines its shapes and function. This process of localized or heterogeneous gene expression is regulated to a large extent at the level of transcription, dictating the degree particular genes in a cell are active. Therefore, errors in the regulation of localized gene expression are at the basis of misregulation of the delicate process of heart development and function. In this review, we provide an overview of the origin of the different components of the vertebrate heart, and discuss our current understanding of the regulation of localized gene expression in the developing heart. We will also discuss where future research may lead to gain more insight into this process, which should provide much needed insight into the dysregulation of heart development and function, and the etiology of congenital defects

U2 - https://doi.org/10.1016/B978-0-12-387786-4.00004-X

DO - https://doi.org/10.1016/B978-0-12-387786-4.00004-X

M3 - Review article

C2 - 22449844

SN - 0070-2153

VL - 100

SP - 171

EP - 201

JO - Current topics in developmental biology

JF - Current topics in developmental biology

ER -