TY - JOUR
T1 - Localized hippocampus measures are associated with Alzheimer pathology and cognition independent of total hippocampal volume
AU - Carmichael, Owen
AU - Xie, Jing
AU - Fletcher, Evan
AU - Singh, Baljeet
AU - Decarli, Charles
AU - AUTHOR GROUP
AU - A, Saradha
AU - Abdi, Hervé
AU - Abdul Hadi, Normi
AU - Abdulkadir, Ahmed
AU - Abdullah, Afnizanfaizal
AU - Achuthan, Anusha
AU - Adluru, Nagesh
AU - Aggarwal, Namita
AU - Aghajanian, Jania
AU - Agyemang, Alex
AU - Ahdidan, Jamila
AU - Ahmad, Duaa
AU - Ahmed, Shiek
AU - Ahmed, Fareed
AU - Ahmed, Fayeza
AU - Akbarifar, Roshanak
AU - Akhondi-Asl, Alireza
AU - Aksu, Yaman
AU - Alcauter, Sarael
AU - Daniel, Alexander
AU - Alin, Aylin
AU - Alshuft, Hamza
AU - Alvarez-Linera, Juan
AU - Amin-Mansour, Ali
AU - Anderson, Dallas
AU - Anderson, Jeff
AU - Andorn, Anne
AU - Ang, Amma
AU - Angersbach, Steve
AU - Ansarian, Reza
AU - Appaji, Abhishek
AU - Appannah, Arti
AU - Arfanakis, Konstantinos
AU - Armentrout, Steven
AU - Arrighi, Michael
AU - Arumughababu, S. Vethanayaki
AU - Arunagiri, Vidhya
AU - Ashe-McNalley, Cody
AU - Ashford, Wes
AU - Aurelie, Le Page
AU - Avants, Brian
AU - Aviv, Richard
AU - Avula, Ramesh
AU - Richard, Edo
AU - Schmand, Ben
PY - 2012
Y1 - 2012
N2 - Hippocampal injury in the Alzheimer's disease (AD) pathological process is region-specific and magnetic resonance imaging (MRI)-based measures of localized hippocampus (HP) atrophy are known to detect region-specific changes associated with clinical AD, but it is unclear whether these measures provide information that is independent of that already provided by measures of total HP volume. Therefore, this study assessed the strength of association between localized HP atrophy measures and AD-related measures including cerebrospinal fluid (CSF) amyloid beta and tau concentrations, and cognitive performance, in statistical models that also included total HP volume as a covariate. A computational technique termed localized components analysis (LoCA) was used to identify 7 independent patterns of HP atrophy among 390 semiautomatically delineated HP from baseline magnetic resonance imaging of participants in the Alzheimer's Disease Neuroimaging Initiative (ADNI). Among cognitively normal participants, multiple measures of localized HP atrophy were significantly associated with CSF amyloid concentration, while total HP volume was not. In addition, among all participants, localized HP atrophy measures and total HP volume were both independently and additively associated with CSF tau concentration, performance on numerous neuropsychological tests, and discrimination between normal, mild cognitive impairment (MCI), and AD clinical diagnostic groups. Together, these results suggest that regional measures of hippocampal atrophy provided by localized components analysis may be more sensitive than total HP volume to the effects of AD pathology burden among cognitively normal individuals and may provide information about HP regions whose deficits may have especially profound cognitive consequences throughout the AD clinical course
AB - Hippocampal injury in the Alzheimer's disease (AD) pathological process is region-specific and magnetic resonance imaging (MRI)-based measures of localized hippocampus (HP) atrophy are known to detect region-specific changes associated with clinical AD, but it is unclear whether these measures provide information that is independent of that already provided by measures of total HP volume. Therefore, this study assessed the strength of association between localized HP atrophy measures and AD-related measures including cerebrospinal fluid (CSF) amyloid beta and tau concentrations, and cognitive performance, in statistical models that also included total HP volume as a covariate. A computational technique termed localized components analysis (LoCA) was used to identify 7 independent patterns of HP atrophy among 390 semiautomatically delineated HP from baseline magnetic resonance imaging of participants in the Alzheimer's Disease Neuroimaging Initiative (ADNI). Among cognitively normal participants, multiple measures of localized HP atrophy were significantly associated with CSF amyloid concentration, while total HP volume was not. In addition, among all participants, localized HP atrophy measures and total HP volume were both independently and additively associated with CSF tau concentration, performance on numerous neuropsychological tests, and discrimination between normal, mild cognitive impairment (MCI), and AD clinical diagnostic groups. Together, these results suggest that regional measures of hippocampal atrophy provided by localized components analysis may be more sensitive than total HP volume to the effects of AD pathology burden among cognitively normal individuals and may provide information about HP regions whose deficits may have especially profound cognitive consequences throughout the AD clinical course
U2 - https://doi.org/10.1016/j.neurobiolaging.2011.08.016
DO - https://doi.org/10.1016/j.neurobiolaging.2011.08.016
M3 - Article
C2 - 22169204
SN - 0197-4580
VL - 33
SP - 1124.e31-1124.e41
JO - Neurobiology of aging
JF - Neurobiology of aging
IS - 6
ER -