@article{2f2ae61b682a4e98a1d9114a04d22f34,
title = "Long Non-coding RNA Aerrie Controls DNA Damage Repair via YBX1 to Maintain Endothelial Cell Function",
abstract = "Aging is accompanied by many physiological changes. These changes can progressively lead to many types of cardiovascular diseases. During this process blood vessels lose their ability to maintain vascular homeostasis, ultimately resulting in hypertension, stroke, or myocardial infarction. Increase in DNA damage is one of the hallmarks of aging and can be repaired by the DNA signaling and repair system. In our study we show that long non-coding RNA Aerrie (linc01013) contributes to the DNA signaling and repair mechanism. Silencing of Aerrie in endothelial cells impairs angiogenesis, migration, and barrier function. Aerrie associates with YBX1 and together they act as important factors in DNA damage signaling and repair. This study identifies Aerrie as a novel factor in genomic stability and as a binding partner of YBX1 in responding to DNA damage.",
keywords = "DNA damage, LncRNA – long non-coding RNA, aging, cardiovascular disease, endothelial cell",
author = "Pham, {Tan Ph{\'a}t} and Bink, {Diewertje I.} and Laura Stanicek and {van Bergen}, Anke and {van Leeuwen}, Esmee and Yvonne Tran and Ljubica Matic and Ulf Hedin and Ilka Wittig and Stefanie Dimmeler and Boon, {Reinier A.}",
note = "Funding Information: This work was supported by the German Centre for Cardiovascular Research (DZHK), the Cardiopulmonary Institute (CPI), the Deutsche Forschungsgemeinschaft (SFB834 to RB and SD, SFB815 to IW, TRR267 to IW, SD, and RB), the European Research Council (“NOVA” to RB and “Angiolnc” to SD), the Netherlands Organisation for Scientific Research (NWO Vidi to RB), the European Union (Horizon 2020 grant no. 825670 to RB). Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2021 Pham, Bink, Stanicek, van Bergen, van Leeuwen, Tran, Matic, Hedin, Wittig, Dimmeler and Boon. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = jan,
day = "11",
doi = "https://doi.org/10.3389/fcell.2020.619079",
language = "English",
volume = "8",
journal = "Frontiers in cell and developmental biology",
issn = "2296-634X",
publisher = "Frontiers Media S.A.",
}