TY - JOUR
T1 - Long noncoding RNAs in cardiometabolic disorders
AU - Juni, Rio P.
AU - 't Hart, Kelly C.
AU - Houtkooper, Riekelt H.
AU - Boon, Reinier A.
N1 - Funding Information: The graphical abstract was created with Biorender.com. Publisher Copyright: © 2022 The Authors. FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.
PY - 2022/5/9
Y1 - 2022/5/9
N2 - The advancement of medical technology has led not only to an increase in life expectancy but also to a rise in aging-related diseases. Aging promotes metabolic disorders, in turn affecting cardiovascular health. Derailment of biological processes in the pancreas, liver, adipose tissue, and skeletal muscle impairs glucose and lipid metabolism, and mitochondrial function, triggering the development of diabetes and lipid-related disorders that inflict damage on cardiac and vascular tissues. Long noncoding RNAs (lncRNAs) regulate a wide range of biological process and are one of the key factors controlling metabolism and mitochondria. Here, we discuss the versatile function of lncRNAs involved in the metabolic regulation of glucose and lipid, and mitochondrial function, and how the dysregulation of lncRNAs induces the development of various metabolic disorders and their cardiovascular consequences.
AB - The advancement of medical technology has led not only to an increase in life expectancy but also to a rise in aging-related diseases. Aging promotes metabolic disorders, in turn affecting cardiovascular health. Derailment of biological processes in the pancreas, liver, adipose tissue, and skeletal muscle impairs glucose and lipid metabolism, and mitochondrial function, triggering the development of diabetes and lipid-related disorders that inflict damage on cardiac and vascular tissues. Long noncoding RNAs (lncRNAs) regulate a wide range of biological process and are one of the key factors controlling metabolism and mitochondria. Here, we discuss the versatile function of lncRNAs involved in the metabolic regulation of glucose and lipid, and mitochondrial function, and how the dysregulation of lncRNAs induces the development of various metabolic disorders and their cardiovascular consequences.
KW - LncRNA
KW - aging
KW - cardiovascular system
KW - glucose and lipid metabolism
KW - mitochondria
UR - http://www.scopus.com/inward/record.url?scp=85130587154&partnerID=8YFLogxK
U2 - https://doi.org/10.1002/1873-3468.14370
DO - https://doi.org/10.1002/1873-3468.14370
M3 - Review article
C2 - 35531641
SN - 0014-5793
VL - 596
SP - 1367
EP - 1387
JO - FEBS letters
JF - FEBS letters
IS - 11
ER -