TY - JOUR
T1 - Long-term effects of premenopausal risk-reducing salpingo-oophorectomy on cognition in women with high familial risk of ovarian cancer
T2 - A cross-sectional study
AU - Terra, L.
AU - Lee Meeuw Kjoe, P.R.
AU - Agelink van Rentergem, J.A.
AU - Beekman, M.J.
AU - Heemskerk-Gerritsen, B.A.M.
AU - van Beurden, M.
AU - Roeters van Lennep, J.E.
AU - van Doorn, H.C.
AU - de Hullu, J.A.
AU - Mourits, M.J.E.
AU - van Dorst, E.B.L.
AU - Mom, C.H.
AU - Slangen, B.F.M.
AU - Gaarenstroom, K.N.
AU - van der Kolk, L.E.
AU - Collée, J.M.
AU - Wevers, M.R.
AU - Ausems, M.G.E.M.
AU - van Engelen, K.
AU - van de Beek, I.
AU - Berger, L.P.V.
AU - van Asperen, C.J.
AU - Gomez Garcia, E.B.
AU - Maas, A.H.E.M.
AU - Hooning, M.J.
AU - van der Wall, E.
AU - van Leeuwen, F.E.
AU - Schagen, S.B.
N1 - With supplementary file
PY - 2023/7
Y1 - 2023/7
N2 - Objective: To examine the effect of a premenopausal risk-reducing salpingo-oophorectomy (RRSO) in women at increased risk of ovarian cancer on objective and subjective cognition at least 10 years after RRSO. Design: A cross-sectional study with prospective follow-up, nested in a nationwide cohort. Setting: Multicentre in the Netherlands. Population or Sample: 641 women (66% BRCA1/2 pathogenic variant carriers) who underwent either a premenopausal RRSO ≤ age 45 (n = 436) or a postmenopausal RRSO ≥ age 54 (n = 205). All participants were older than 55 years at recruitment. Methods: Participants completed an online cognitive test battery and a questionnaire on subjective cognition. We used multivariable regression analyses, adjusting for age, education, breast cancer, hormone replacement therapy, cardiovascular risk factors and depression. Main Outcome Measures: The influence of RRSO on objective and subjective cognition of women with a premenopausal RRSO compared with women with a postmenopausal RRSO. Results: After adjustment, women with a premenopausal RRSO (mean time since RRSO 18.2 years) performed similarly on objective cognitive tests compared with women with a postmenopausal RRSO (mean time since RRSO 11.9 years). However, they more frequently reported problems with reasoning (odds ratio [OR] 1.8, 95% confidence interval [95% CI] 1.1–3.1) and multitasking (OR 1.9, 95% CI 1.1–3.4) than women with a postmenopausal RRSO. This difference between groups disappeared in an analysis restricted to women of comparable ages (60–70 years). Conclusions: Reassuringly, approximately 18 years after RRSO, we found no association between premenopausal RRSO and objective cognition.
AB - Objective: To examine the effect of a premenopausal risk-reducing salpingo-oophorectomy (RRSO) in women at increased risk of ovarian cancer on objective and subjective cognition at least 10 years after RRSO. Design: A cross-sectional study with prospective follow-up, nested in a nationwide cohort. Setting: Multicentre in the Netherlands. Population or Sample: 641 women (66% BRCA1/2 pathogenic variant carriers) who underwent either a premenopausal RRSO ≤ age 45 (n = 436) or a postmenopausal RRSO ≥ age 54 (n = 205). All participants were older than 55 years at recruitment. Methods: Participants completed an online cognitive test battery and a questionnaire on subjective cognition. We used multivariable regression analyses, adjusting for age, education, breast cancer, hormone replacement therapy, cardiovascular risk factors and depression. Main Outcome Measures: The influence of RRSO on objective and subjective cognition of women with a premenopausal RRSO compared with women with a postmenopausal RRSO. Results: After adjustment, women with a premenopausal RRSO (mean time since RRSO 18.2 years) performed similarly on objective cognitive tests compared with women with a postmenopausal RRSO (mean time since RRSO 11.9 years). However, they more frequently reported problems with reasoning (odds ratio [OR] 1.8, 95% confidence interval [95% CI] 1.1–3.1) and multitasking (OR 1.9, 95% CI 1.1–3.4) than women with a postmenopausal RRSO. This difference between groups disappeared in an analysis restricted to women of comparable ages (60–70 years). Conclusions: Reassuringly, approximately 18 years after RRSO, we found no association between premenopausal RRSO and objective cognition.
KW - BRCA1/2 pathogenic variant carriers
KW - cognitive functioning
KW - premature menopause
KW - risk-reducing salpingo-oophorectomy
UR - http://www.scopus.com/inward/record.url?scp=85148518713&partnerID=8YFLogxK
UR - https://pure.uva.nl/ws/files/190291362/bjo17415-sup-0001-appendixs1.docx
U2 - 10.1111/1471-0528.17415
DO - 10.1111/1471-0528.17415
M3 - Article
C2 - 36715559
SN - 1470-0328
VL - 130
SP - 968
EP - 977
JO - BJOG: An International Journal of Obstetrics and Gynaecology
JF - BJOG: An International Journal of Obstetrics and Gynaecology
IS - 8
ER -