Long-term memory response after a single intramuscular rabies booster vaccination, 10-24 years after primary immunization

Cornelis A De Pijper; Annefleur C Langedijk; Sanne Terryn; Steven Van Gucht; Martin P Grobusch; Abraham Goorhuis; Cornelis Stijnis

doi:https://doi.org/10.1093/infdis/jiab034

Long-term memory response after a single intramuscular rabies booster vaccination, 10-24 years after primary immunization

Cornelis A De Pijper, Annefleur C Langedijk, Sanne Terryn, Steven Van Gucht, Martin P Grobusch, Abraham Goorhuis, Cornelis Stijnis

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: To date, published data regarding long-lasting immunological rabies memory after a pre-exposure prophylaxis (PrEP)-schedule are scarce. We tested the hypothesis that rabies booster immunization elicits rapid anamnestic responses.

METHODS: For this observational study, we included participants who had received PrEP 10-24 years before inclusion. We measured rabies antibody titers before, and on days 3, 7 and 14 after one single intramuscular booster.

RESULTS: All 28 participants responded adequately regardless route of administration or (2-dose vs. 3-dose) PrEP-regimen.

CONCLUSION: Rabies immunological memory is reactivated within 7 days after a single intramuscular booster immunization, even when administered 10-24 years after PrEP.

Original language	English
Journal	Journal of infectious diseases
DOIs	https://doi.org/10.1093/infdis/jiab034
Publication status	E-pub ahead of print - 27 Jan 2021

Access to Document

https://doi.org/10.1093/infdis/jiab034

Cite this

@article{7254532357a94a5fa688b84c57dcd98c,

title = "Long-term memory response after a single intramuscular rabies booster vaccination, 10-24 years after primary immunization",

abstract = "BACKGROUND: To date, published data regarding long-lasting immunological rabies memory after a pre-exposure prophylaxis (PrEP)-schedule are scarce. We tested the hypothesis that rabies booster immunization elicits rapid anamnestic responses.METHODS: For this observational study, we included participants who had received PrEP 10-24 years before inclusion. We measured rabies antibody titers before, and on days 3, 7 and 14 after one single intramuscular booster.RESULTS: All 28 participants responded adequately regardless route of administration or (2-dose vs. 3-dose) PrEP-regimen.CONCLUSION: Rabies immunological memory is reactivated within 7 days after a single intramuscular booster immunization, even when administered 10-24 years after PrEP.",

author = "{De Pijper}, {Cornelis A} and Langedijk, {Annefleur C} and Sanne Terryn and {Van Gucht}, Steven and Grobusch, {Martin P} and Abraham Goorhuis and Cornelis Stijnis",

note = "{\textcopyright} The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America.",

year = "2021",

month = jan,

day = "27",

doi = "https://doi.org/10.1093/infdis/jiab034",

language = "English",

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T1 - Long-term memory response after a single intramuscular rabies booster vaccination, 10-24 years after primary immunization

AU - De Pijper, Cornelis A

AU - Langedijk, Annefleur C

AU - Terryn, Sanne

AU - Van Gucht, Steven

AU - Grobusch, Martin P

AU - Goorhuis, Abraham

AU - Stijnis, Cornelis

PY - 2021/1/27

Y1 - 2021/1/27

N2 - BACKGROUND: To date, published data regarding long-lasting immunological rabies memory after a pre-exposure prophylaxis (PrEP)-schedule are scarce. We tested the hypothesis that rabies booster immunization elicits rapid anamnestic responses.METHODS: For this observational study, we included participants who had received PrEP 10-24 years before inclusion. We measured rabies antibody titers before, and on days 3, 7 and 14 after one single intramuscular booster.RESULTS: All 28 participants responded adequately regardless route of administration or (2-dose vs. 3-dose) PrEP-regimen.CONCLUSION: Rabies immunological memory is reactivated within 7 days after a single intramuscular booster immunization, even when administered 10-24 years after PrEP.

AB - BACKGROUND: To date, published data regarding long-lasting immunological rabies memory after a pre-exposure prophylaxis (PrEP)-schedule are scarce. We tested the hypothesis that rabies booster immunization elicits rapid anamnestic responses.METHODS: For this observational study, we included participants who had received PrEP 10-24 years before inclusion. We measured rabies antibody titers before, and on days 3, 7 and 14 after one single intramuscular booster.RESULTS: All 28 participants responded adequately regardless route of administration or (2-dose vs. 3-dose) PrEP-regimen.CONCLUSION: Rabies immunological memory is reactivated within 7 days after a single intramuscular booster immunization, even when administered 10-24 years after PrEP.

U2 - https://doi.org/10.1093/infdis/jiab034

DO - https://doi.org/10.1093/infdis/jiab034

M3 - Article

C2 - 33502530

SN - 0022-1899

JO - Journal of infectious diseases

JF - Journal of infectious diseases

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