TY - JOUR
T1 - Long-Term Oncological Outcomes of Papillary Thyroid Cancer and Follicular Thyroid Cancer in Children
T2 - A Nationwide Population-Based Study
AU - van de Berg, Daniël J.
AU - Kuijpers, Anke M. J.
AU - Engelsman, Anton F.
AU - Drukker, Caroline A.
AU - van Santen, Hanneke M.
AU - Terwisscha van Scheltinga, Sheila C. E. J.
AU - van Trotsenburg, A. S. Paul
AU - Mooij, Christiaan F.
AU - Vriens, Menno R.
AU - Nieveen van Dijkum, Els J. M.
AU - Derikx, Joep P. M.
N1 - Funding Information: The authors thank ‘Stichting Steun Emma Kinderziekenhuis’ for their support in making this study possible. The authors thank the registration team of the Netherlands Comprehensive Cancer Organization (IKNL) for the collection of data for the Netherlands Cancer Registry as well as IKNL staff for scientific advice. The authors thank “the Nationwide network and registry of histo- and cytopathology in the Netherlands” (PALGA) for providing us with valuable pathology reports. Publisher Copyright: Copyright © 2022 van de Berg, Kuijpers, Engelsman, Drukker, van Santen, Terwisscha van Scheltinga, van Trotsenburg, Mooij, Vriens, Nieveen van Dijkum and Derikx.
PY - 2022/5/4
Y1 - 2022/5/4
N2 - Introduction: Pediatric thyroid carcinoma is a rare malignancy and data on long-term oncological outcomes are sparse. The aim of this study was to describe the long-term oncological outcomes of pediatric papillary thyroid carcinoma (PTC) and follicular thyroid carcinoma (FTC) in a national cohort, and to identify risk factors for recurrence. Methods: We conducted a nationwide, retrospective cohort study, in which we combined two national databases. Patients aged <18 years, diagnosed with PTC or FTC in the Netherlands between 2000 and 2016, were included. pT-stage, pN-stage, multifocality and angioinvasion were included in a Cox-regression analysis for the identification of risk factors for recurrence. Results: 133 patients were included: 110 with PTC and 23 with FTC. Patients with PTC most often presented with pT2 tumors (24%) and pN1b (45%). During a median follow-up of 11.3 years, 21 patients with PTC developed a recurrence (19%). Nineteen recurrences were regional (91%) and 2 were pulmonary (9%). No risk factors for recurrence could be determined. One patient who developed pulmonary recurrence died two years later. Cause of death was not captured. Patients with FTC most often presented with pT2 tumors (57%). One patient presented with pN1b (4%). In 70%, no lymph nodes were collected. None of the patients with FTC developed a recurrence or died. Conclusion: Pediatric PTC and FTC are two distinct diseases. Recurrence in pediatric PTC is common, but in FTC it is not. Survival for both pediatric PTC and FTC is very good.
AB - Introduction: Pediatric thyroid carcinoma is a rare malignancy and data on long-term oncological outcomes are sparse. The aim of this study was to describe the long-term oncological outcomes of pediatric papillary thyroid carcinoma (PTC) and follicular thyroid carcinoma (FTC) in a national cohort, and to identify risk factors for recurrence. Methods: We conducted a nationwide, retrospective cohort study, in which we combined two national databases. Patients aged <18 years, diagnosed with PTC or FTC in the Netherlands between 2000 and 2016, were included. pT-stage, pN-stage, multifocality and angioinvasion were included in a Cox-regression analysis for the identification of risk factors for recurrence. Results: 133 patients were included: 110 with PTC and 23 with FTC. Patients with PTC most often presented with pT2 tumors (24%) and pN1b (45%). During a median follow-up of 11.3 years, 21 patients with PTC developed a recurrence (19%). Nineteen recurrences were regional (91%) and 2 were pulmonary (9%). No risk factors for recurrence could be determined. One patient who developed pulmonary recurrence died two years later. Cause of death was not captured. Patients with FTC most often presented with pT2 tumors (57%). One patient presented with pN1b (4%). In 70%, no lymph nodes were collected. None of the patients with FTC developed a recurrence or died. Conclusion: Pediatric PTC and FTC are two distinct diseases. Recurrence in pediatric PTC is common, but in FTC it is not. Survival for both pediatric PTC and FTC is very good.
KW - children
KW - follicular thyroid cancer
KW - long-term oncologic outcomes
KW - papillary thyroid cancer
KW - pediatric
UR - http://www.scopus.com/inward/record.url?scp=85130513548&partnerID=8YFLogxK
U2 - https://doi.org/10.3389/fendo.2022.899506
DO - https://doi.org/10.3389/fendo.2022.899506
M3 - Article
C2 - 35600573
SN - 1664-2392
VL - 13
JO - Frontiers in Endocrinology
JF - Frontiers in Endocrinology
M1 - 899506
ER -