Loss of CD47 Makes Dendritic Cells See Red

Timo K van den Berg; Robin van Bruggen

doi:https://doi.org/10.1016/j.immuni.2015.09.008

Loss of CD47 Makes Dendritic Cells See Red

Timo K van den Berg, Robin van Bruggen

Research output: Contribution to journal › Article › Academic › peer-review

6 Citations (Scopus)

Abstract

Whereas dendritic cells (DCs) can be activated in many ways to trigger immunity, hardly anything is known about the mechanisms that counterbalance DC activation. Cyster and colleagues now demonstrate that the "self" molecule CD47 on erythrocytes critically restricts splenic DC activation.

Original language	English
Pages (from-to)	622-4
Number of pages	3
Journal	Immunity
Volume	43
Issue number	4
DOIs	https://doi.org/10.1016/j.immuni.2015.09.008
Publication status	Published - 20 Oct 2015

Keywords

Adaptive Immunity
Animals
CD47 Antigen/blood
Dendritic Cells/immunology
Erythrocytes/immunology
Receptors, Immunologic/immunology
Self Tolerance/immunology
Spleen/immunology

Access to Document

https://doi.org/10.1016/j.immuni.2015.09.008

Cite this

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title = "Loss of CD47 Makes Dendritic Cells See Red",

abstract = "Whereas dendritic cells (DCs) can be activated in many ways to trigger immunity, hardly anything is known about the mechanisms that counterbalance DC activation. Cyster and colleagues now demonstrate that the {"}self{"} molecule CD47 on erythrocytes critically restricts splenic DC activation. ",

keywords = "Adaptive Immunity, Animals, CD47 Antigen/blood, Dendritic Cells/immunology, Erythrocytes/immunology, Receptors, Immunologic/immunology, Self Tolerance/immunology, Spleen/immunology",

author = "{van den Berg}, {Timo K} and {van Bruggen}, Robin",

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AU - van Bruggen, Robin

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AB - Whereas dendritic cells (DCs) can be activated in many ways to trigger immunity, hardly anything is known about the mechanisms that counterbalance DC activation. Cyster and colleagues now demonstrate that the "self" molecule CD47 on erythrocytes critically restricts splenic DC activation.

KW - Adaptive Immunity

KW - Animals

KW - CD47 Antigen/blood

KW - Dendritic Cells/immunology

KW - Erythrocytes/immunology

KW - Receptors, Immunologic/immunology

KW - Self Tolerance/immunology

KW - Spleen/immunology

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DO - https://doi.org/10.1016/j.immuni.2015.09.008

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