Whereas dendritic cells (DCs) can be activated in many ways to trigger immunity, hardly anything is known about the mechanisms that counterbalance DC activation. Cyster and colleagues now demonstrate that the "self" molecule CD47 on erythrocytes critically restricts splenic DC activation.
- Adaptive Immunity
- CD47 Antigen/blood
- Dendritic Cells/immunology
- Receptors, Immunologic/immunology
- Self Tolerance/immunology