Low level of HIV-1 evolution after transmission from mother to child

Esther F. Gijsbers; Ad C. van Nuenen; Alba Torrents de la Peňa; Emma J. Bowles; Guillaume B. Stewart-Jones; Hanneke Schuitemaker; Neeltje A. Kootstra

doi:https://doi.org/10.1038/srep05079

Low level of HIV-1 evolution after transmission from mother to child

Esther F. Gijsbers, Ad C. van Nuenen, Alba Torrents de la Peňa, Emma J. Bowles, Guillaume B. Stewart-Jones, Hanneke Schuitemaker, Neeltje A. Kootstra

Research output: Contribution to journal › Article › Academic › peer-review

6 Citations (Scopus)

Abstract

Mother-to-child HIV-1 transmission pairs represent a good opportunity to study the dynamics of CTL escape and reversion after transmission in the light of shared and non-shared HLA-alleles. Mothers share half of their HLA alleles with their children, while the other half is inherited from the father and is generally discordant between mother and child. This implies that HIV-1 transmitted from mother to child enters a host environment to which it has already partially adapted. Here, we studied viral evolution and the dynamics of CTL escape mutations and reversion of these mutations after transmission in the context of shared and non-shared HLA alleles in viral variants obtained from five mother-to-child transmission pairs. Only limited HIV-1 evolution was observed in the children after mother-to-child transmission. Viral evolution was mainly driven by forward mutations located inside CTL epitopes restricted by HLA alleles inherited from the father, which may be indicative of CTL pressure

Original language	English
Pages (from-to)	5079
Journal	Scientific reports
Volume	4
DOIs	https://doi.org/10.1038/srep05079
Publication status	Published - 2014

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https://doi.org/10.1038/srep05079

Cite this

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title = "Low level of HIV-1 evolution after transmission from mother to child",

abstract = "Mother-to-child HIV-1 transmission pairs represent a good opportunity to study the dynamics of CTL escape and reversion after transmission in the light of shared and non-shared HLA-alleles. Mothers share half of their HLA alleles with their children, while the other half is inherited from the father and is generally discordant between mother and child. This implies that HIV-1 transmitted from mother to child enters a host environment to which it has already partially adapted. Here, we studied viral evolution and the dynamics of CTL escape mutations and reversion of these mutations after transmission in the context of shared and non-shared HLA alleles in viral variants obtained from five mother-to-child transmission pairs. Only limited HIV-1 evolution was observed in the children after mother-to-child transmission. Viral evolution was mainly driven by forward mutations located inside CTL epitopes restricted by HLA alleles inherited from the father, which may be indicative of CTL pressure",

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AU - Gijsbers, Esther F.

AU - van Nuenen, Ad C.

AU - de la Peňa, Alba Torrents

AU - Bowles, Emma J.

AU - Stewart-Jones, Guillaume B.

AU - Schuitemaker, Hanneke

AU - Kootstra, Neeltje A.

PY - 2014

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AB - Mother-to-child HIV-1 transmission pairs represent a good opportunity to study the dynamics of CTL escape and reversion after transmission in the light of shared and non-shared HLA-alleles. Mothers share half of their HLA alleles with their children, while the other half is inherited from the father and is generally discordant between mother and child. This implies that HIV-1 transmitted from mother to child enters a host environment to which it has already partially adapted. Here, we studied viral evolution and the dynamics of CTL escape mutations and reversion of these mutations after transmission in the context of shared and non-shared HLA alleles in viral variants obtained from five mother-to-child transmission pairs. Only limited HIV-1 evolution was observed in the children after mother-to-child transmission. Viral evolution was mainly driven by forward mutations located inside CTL epitopes restricted by HLA alleles inherited from the father, which may be indicative of CTL pressure

U2 - https://doi.org/10.1038/srep05079

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