TY - JOUR
T1 - Lymph vessels: the forgotten second circulation in health and disease
AU - Adamczyk, Lukasz A.
AU - Gordon, Kristiana
AU - Kholová, Ivana
AU - Meijer-Jorna, Lorine B.
AU - Telinius, Niklas
AU - Gallagher, Patrick J.
AU - van der Wal, Allard C.
AU - Baandrup, Ulrik
PY - 2016
Y1 - 2016
N2 - The lymphatic circulation is still a somewhat forgotten part of the circulatory system. Despite this, novel insights in lymph angiogenesis in health and disease, application of immune markers for lymphatic growth and differentiation and also the introduction of new imaging techniques to visualize the lymphatic circulation have improved our understanding of lymphatic function in both health and disease, especially in the last decade. These achievements yield better understanding of the various manifestations of lymph oedemas and malformations, and also the patterns of lymphovascular spread of cancers. Immune markers that recognize lymphatic endothelium antigens, such as podoplanin, LYVE-1 and Prox-1, can be successfully applied in diagnostic pathology and have revealed (at least partial) lymphatic differentiation in many types of vascular lesions
AB - The lymphatic circulation is still a somewhat forgotten part of the circulatory system. Despite this, novel insights in lymph angiogenesis in health and disease, application of immune markers for lymphatic growth and differentiation and also the introduction of new imaging techniques to visualize the lymphatic circulation have improved our understanding of lymphatic function in both health and disease, especially in the last decade. These achievements yield better understanding of the various manifestations of lymph oedemas and malformations, and also the patterns of lymphovascular spread of cancers. Immune markers that recognize lymphatic endothelium antigens, such as podoplanin, LYVE-1 and Prox-1, can be successfully applied in diagnostic pathology and have revealed (at least partial) lymphatic differentiation in many types of vascular lesions
U2 - https://doi.org/10.1007/s00428-016-1945-6
DO - https://doi.org/10.1007/s00428-016-1945-6
M3 - Review article
C2 - 27173782
SN - 0945-6317
VL - 469
SP - 3
EP - 17
JO - Virchows Archiv
JF - Virchows Archiv
IS - 1
ER -