Lysosomal secretion of Flightless I upon injury has the potential to alter inflammation

Allison J. Cowin, Nazi Lei, Linda Franken, Nadira Ruzehaji, Carolin Offenhäuser, Zlatko Kopecki, Rachael Z. Murray

Research output: Contribution to JournalArticleAcademicpeer-review

9 Citations (Scopus)

Abstract

Intracellular Flightless I (Flii), a gelsolin family member, has been found to have roles modulating actin regulation, transcriptional regulation and inflammation. In vivo Flii can regulate wound healing responses. We have recently shown that a pool of Flii is secreted by fibroblasts and macrophages, cells typically found in wounds, and its secretion can be upregulated upon wounding. We show that secreted Flii can bind to the bacterial cell wall component lipopolysaccharide and has the potential to regulate inflammation. We now show that secreted Flii is present in both acute and chronic wound fluid.

Original languageEnglish
Pages (from-to)546-549
Number of pages4
JournalCommunicative & Integrative Biology
Volume5
Issue number6
DOIs
Publication statusPublished - Nov 2012

Keywords

  • Cathepsin D
  • Flightless I
  • Late endosome
  • Lysosome
  • Rab 7 and Stx11
  • Secretion

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