TY - JOUR
T1 - Macrophages in Lupus Nephritis
T2 - Exploring a potential new therapeutic avenue
AU - Kwant, Lianne E.
AU - Vegting, Yosta
AU - Tsang-a-Sjoe, Michel W. P.
AU - Kwakernaak, Arjan J.
AU - Vogt, Liffert
AU - Voskuyl, Alexandre E.
AU - van Vollenhoven, Ronald F.
AU - de Winther, Menno P. J.
AU - Bemelman, Frederike J.
AU - Anders, Hans-Joachim
AU - Hilhorst, Marc L.
N1 - Funding Information: This work was supported by the Dutch Kidney Foundation [grant numbers 19OK007 , 21OSR007 ]. Publisher Copyright: © 2022 The Authors
PY - 2022/12/1
Y1 - 2022/12/1
N2 - Lupus nephritis (LN) is a serious complication of systemic lupus erythematosus (SLE) that occurs in about half of patients. LN is characterized by glomerular deposition of immune complexes, leading to subendothelial, mesangial and subepithelial electron dense deposits, triggering immune cell infiltration and glomerular as well as tubulointerstitial injury. Monocytes and macrophages are abundantly present in inflammatory lesions, both in glomeruli and the tubulointerstitium. Here we discuss how monocytes and macrophages are involved in this process and how monocytes and macrophages may represent specific therapeutic targets to control LN.
AB - Lupus nephritis (LN) is a serious complication of systemic lupus erythematosus (SLE) that occurs in about half of patients. LN is characterized by glomerular deposition of immune complexes, leading to subendothelial, mesangial and subepithelial electron dense deposits, triggering immune cell infiltration and glomerular as well as tubulointerstitial injury. Monocytes and macrophages are abundantly present in inflammatory lesions, both in glomeruli and the tubulointerstitium. Here we discuss how monocytes and macrophages are involved in this process and how monocytes and macrophages may represent specific therapeutic targets to control LN.
KW - Kidney
KW - Lupus
KW - Macrophage
KW - Nephritis
KW - Treatment
UR - http://www.scopus.com/inward/record.url?scp=85140057421&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.autrev.2022.103211
DO - https://doi.org/10.1016/j.autrev.2022.103211
M3 - Review article
C2 - 36252930
SN - 1568-9972
VL - 21
JO - Autoimmunity Reviews
JF - Autoimmunity Reviews
IS - 12
M1 - 103211
ER -